活性氧诱导离体大鼠耳蜗Corti器毛细胞凋亡的观察
Observation of Reactive Oxygen Species on the Apoptosis of H_2O_2 Cochlear Hair Cell of Organ of Corti in Rat
原红艳;张淑香;李兴启;李树华;
1:天津武警医学院附属医院耳鼻咽喉科
2:中国人民解放军耳鼻咽喉科研究所
3:沈阳军区总医院耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1 Rao D,Fechter LD.Protective effects of phenyl-N-tert-butylni-trone on the potentiation of noise-induced hearing loss by carbonmonoxide[J].Toxicol-Appl-Pharmacol,2000,167:125.
2 Sha SH,Taylor R,Forge A.Differential vulnerability of basaland apical hair cells is based on intrinsic susceptibility to freeradicals[J].Hear Res,2001,155:1.
3 Choi HS,Park KJ,Hwang SC,et al.The role of peroxiredo-xin III in the ototoxic drug-induced mitochondrial apoptosisof cochlear hair cells[J].Acta Otolaryngol.,2008,128:944.
4 Kim SJ,Park C,Han AL et al.Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditorycells[J].Hear Res,2009,251:70.
5 Fetoni AR,Piacentini R,Fiorita A,et al.Water-soluble Co-enzyme Q10 formulation(Q-ter)promotes outer hair cellsurvival in a guinea pig model of noise induced hearing loss(NIHL)[J].Brain Res,2009,1257:108.
6 Jamesdaniel S,Ding D,Habiby Kermany M,et al.Analysis ofcochlear protein profiles of Wistar,Sprague-Dawley and Fis-cher 344 rats with normal hearing function[J].Journal of Pro-teome Research,2009,11:1.
7 Lim HW,Choi SH,Kang HH,et al.Apoptotic pattern of co-chlear outer hair cells and frequency-specific hearing thre-shold shift in noise-exposed BALB/c mice[J].Clin Exp Oto-rhinolaryngol,2008,1:80.
8 Clerici WJ,DiMartino DL,Presad MR.Direct effects of reac-tive oxygen species on cochlear outer hair cell shape in vitro[J].Hear Res,1995,84:30.
9 Matsunobu T,Schacht J.Nitric oxide/cyclic GMP pathway attenu-ates ATP-evoked intracellular calcium increase in supporting cells ofthe guinea pig cochlea[J].J Compar Neubio,2000,423:452.
10 Lorito G,Giordano P,Petruccelli J,et al.Different strategiesin treating noiseinduced hearing loss with N-acetylcysteine[J].Med Sci Monit,2008,14:159.