镍钛记忆合金支架治疗兔外耳道狭窄的实验研究

An Experiment of Using Nitinol Alloy Momemorial Stent to Treat the Stenosis of the Rabbi

王孟冬;黄志纯;顾建兴;孙宝宾;冯旭;

1:南京东南大学附属中大医院耳鼻喉科

摘要
目的比较镍钛记忆合金支架与硅胶管治疗兔外耳道瘢痕狭窄的疗效。方法将16只外耳道瘢痕狭窄的新西兰大白兔,随机分为植皮组和不植皮组各8只,各组在兔的双侧外耳道分别植入镍钛记忆合金支架和硅胶管,在植入后5、15、30、60天时,植皮组测量两侧的外耳道直径变化;不植皮组分别取双侧外耳道瘢痕组织HE染色观察瘢痕中成纤维细胞变化、RT-PCR检测转化生长因子β1mRNA(TGFβ1)表达,比较两种材料抑制瘢痕增生的效果。结果植皮组使用镍钛记忆合金支架侧各时间点兔外耳道直径明显大于硅胶管侧;不植皮组植入镍钛记忆合金支架侧外耳道瘢痕组织中成纤维细胞数明显少于植入硅胶管侧(P<0.05),TGFβ1mRNA表达亦明显较硅胶管侧降低(P<0.05)。结论镍钛记忆合金支架在治疗兔外耳道狭窄方面疗效显著优于传统的硅胶管。
关键词
镍钛记忆合金支架;外耳道;瘢痕;模型;动物
基金项目(Foundation):
作者
王孟冬;黄志纯;顾建兴;孙宝宾;冯旭;
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