反流性喉炎与声带白斑关系的初步探讨

The Potential Relationship between Reflux Laryngitis and Vocal Leukoplakia

庄佩耘;周莉;郝玲;张帆;郭永清;蒋家琪;

1:厦门大学附属中山医院耳鼻咽喉科

2:复旦大学附属眼耳鼻喉科医院耳鼻咽喉科

摘要
目的探讨反流性喉炎与声带白斑的关系。方法2009年3月2009年11月在厦门大学附属中山医院耳鼻咽喉科经临床和病理诊断为声带白斑同时合并反流性喉炎的8例患者,予以62009年11月在厦门大学附属中山医院耳鼻咽喉科经临床和病理诊断为声带白斑同时合并反流性喉炎的8例患者,予以68周的质子泵抑制剂(PPI)抗反流治疗,治疗前后分别进行频闪喉镜检查、嗓音主客观声学评估、嗓音障碍指数以及反流性喉炎症状评分量表和体征发现量表的评估。结果8例患者反流性喉炎均治愈,频闪喉镜、主客观声学分析结果显示治疗后较治疗前均有所改善;8例患者声带白斑完全消失,随诊38周的质子泵抑制剂(PPI)抗反流治疗,治疗前后分别进行频闪喉镜检查、嗓音主客观声学评估、嗓音障碍指数以及反流性喉炎症状评分量表和体征发现量表的评估。结果8例患者反流性喉炎均治愈,频闪喉镜、主客观声学分析结果显示治疗后较治疗前均有所改善;8例患者声带白斑完全消失,随诊35个月未见声带白斑复发。结论反流性喉炎与声带白斑可能存在某种关联,其在声带白斑的发生发展中起一定的作用,临床中应注意对声带白斑患者进行反流性喉炎的评估,PPI治疗可使部分患者避免手术。
关键词
声带白斑;反流性喉炎;质子泵抑制剂治疗;嗓音疾病评估
基金项目(Foundation):
作者
庄佩耘;周莉;郝玲;张帆;郭永清;蒋家琪;
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