感音神经性聋患者失匹配负波特征分析

Mismatch Negativity in Patients with Sensorineural Hearing Loss

马峰杰;刘莎;鲜军舫;王振常;郭连生;秦鹏民;赵金萍;林思恩;宋雯;刘美玉;

1:首都医科大学附属北京同仁医院耳鼻咽喉头颈外科

2:首都医科大学附属北京同仁医院放射科

3:北京市耳鼻咽喉科研究所

4:中国科学院心理研究所

摘要
目的初步研究感音神经性聋患者短纯音刺激失匹配负波(mismatch negativity,MMN)的变化特征。方法采用美国32导Neuroscan EEG/ERP记录系统对24例(48耳)听力正常受试者和7例(14耳)感音神经性聋患者进行MMN测试。采用经典Oddball模式,标准刺激和偏差刺激分别为500Hz和1000Hz的短纯音测试两组受试者MMN,比较两组MMN潜伏期和波幅的差异。结果感音神经性聋组MMN潜伏期为145.00±16.11ms,与对照组130.45±7.31ms相比,明显延长(P=0.009),两组的波幅改变无统计学意义(P=0.908)。而两组的波幅变异系数(CV%)均大于对应潜伏期的变异系数(CV%)。结论感音神经性聋患者MMN的潜伏期明显延长,波幅变化不大。MMN潜伏期相对比较稳定,但波幅个体间差异较大。
关键词
感音神经性聋;失匹配负波;事件相关电位
基金项目(Foundation):
北京市自然科学基金(7062019);; 北京市教育委员会科技发展计划面上项目(KM200710025020);; 高等学校博士学科点专项科研基金(20060025002);; 北京市科技新星计划(B类)2004-B-31;; 北京市自然科学基金(7082026)资助
作者
马峰杰;刘莎;鲜军舫;王振常;郭连生;秦鹏民;赵金萍;林思恩;宋雯;刘美玉;
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