中青年OSAHS患者缺氧程度与认知功能损害的相关性研究

The Correlation between the Degree of Pathogenetic Condition and Cognitive Impairment in Young OSAHS Patients

辛忠海;王宁宇;李金兰;陈琢;温晓慧;

1:首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科

摘要

目的探讨青年OSAHS患者缺氧程度与认知功能的相关性。方法选取OSAHS患者63例,年龄18～44岁。根据OSAHS患者的低氧血症程度,将患者分为轻度组20例(最低SaO2≥85%),中度组24例(最低SaO265%～84%),重度组19例(最低SaO2<65%);对照组25例(正常人:AHI<5)。均进行事件相关电位P300、多导睡眠图(polysomnogram,PSG)和简易智能精神状态检查量表(mini-mental state examination,MMSE)检测。结果①OSAHS患者轻度、中度、重度三组P300潜伏期分别为326.1±12.7、346.9±19.1、334.9±18.3ms,与对照组311.9±18.3ms比较差异均有统计学意义(皆P<0.05),OSAHS轻、中度组与重度组之间差异均有统计学意义(P<0.01或P<0.05),但轻度组和中度组患者之间差异无统计学意义(P=0.095);②重度组中因最低血氧持续时间的不同P300潜伏期不同:最低血氧持续时间4～60秒组潜伏期为338.12±13.7ms,最低血氧持续时间61～140秒组潜伏期为354.74±16.7ms,差异有统计学意义(P=0.031);③以上各组P300波幅之间比较差异无统计学意义;④所有患者MESS得分均在正常范围内,但部分得分稍低,重度组与对照组得分比较差异有统计学意义(R-A-R-B=9.91,P=0.003)。结论OSAHS患者普遍存在认知功能障碍,可以最低血氧程度及其持续时间初步评估认知功能损害的程度。

关键词

阻塞性睡眠呼吸暂停低通气综合征;事件相关电位P300;认知功能损害;程度

基金项目(Foundation):

作者

辛忠海;王宁宇;李金兰;陈琢;温晓慧;

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阻塞性睡眠呼吸暂停低通气综合征事件相关电位P300 认知功能损害程度

本文作者相关文章

辛忠海王宁宇李金兰陈琢温晓慧