大鼠耳蜗组织中Nedd4及SGK1的表达
Expression Patterns of Nedd4 Isoforms and SGK1 in the Rat Cochlea
钟时勋;刘兆华;
1:重庆医科大学附属第一医院耳鼻咽喉科
2:第三军医大学附属大坪医院耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1 Zhong SX,Liu ZH.Immunohistochemical localization of theepithelial sodium channel in the rat inner ear[J].Hear Res,2004,193:1.
2钟时勋,刘兆华.豚鼠耳蜗和内淋巴束上皮钠通道的表达[J].中华耳鼻咽喉头颈外科杂志,2009,44:49.
3 Duc C,Farman N,Canessa CM,et al.Cell-specific expres-sion of epithelial sodium channelα,β,andγsubunits in aldo-sterone-responsive epithelia from the rat:localization by insitu hybridization and immunocytochemistry[J].J Cell Biol,1994,127:1 907.
4 Garty H,Palmer LG.Epithelial sodium channels:function,structure,and regulation[J].Physiol Rev,1997,77:359.
5 Kamynina E,Staub O.Concerted action of ENaC,Nedd4-2,and SGK1 in transepithelial Na+transport[J].Am J PhysiolRenal Physiol,2002,283:F377.
6 Faletti CJ,Perrotti N,Taylor SI,et al.SGK:an essentialconvergence point for peptide and steroid hormone regulationof ENaC-mediated Na+transport[J].Am J Physiol CellPhysiol,2002,282:C494.
7 Staub O,Yeger H,Plant P,et al.Immunolocalization of theubiquitin-protein ligase Nedd4 in tissues expressing the epi-thelial Na+channel(ENaC)[J].Am J Physiol,1997,272:C1871.
8 Hou J,Speirs HJL,Seckl J,et al.SGK1 gene expression inkidney and its regulation by aldosterone:spatio-temporalheterogeneity and quantitative analysis[J].J Am Soc Neph-rol,2002,13:1 190.
9 Kamynina E,Debonneville C,Bens M,et al.A novel mouseNedd4 protein suppresses the activity of the epithelial Na+channel[J].FASEB J,2001,15:204.
10 Staub O,Dho S,Henry PC,et al.WWdomains of Nedd4bind to the porline-rich PY motifs in the epithelial Na+channel deletedin Liddle's syndrome[J].EMBO J,1996,15:2 371.
11 Staub O,Abriel H,Plant P,et al.Regulation of the epithe-lial Na+channel by Nedd4 and ubiquitination[J].KidneyInt,2000,57:809.
12 Stockand JD.Newideas about aldosterone signaling in epi-thelia[J].AmJ Physiol Renal Physiol,2002,282:F559.
13刘博,刘铤.前庭生理[M].见:刘铤,主编.内耳病.北京:人民卫生出版社,2006.59~80.
14 Naftalin L.The possible roles of hormones and enzymes inthe production of the acute attack in Meniere's disease[J].Eur Arch Otorhinolaryngol,1994,251:173.
15 Rarey KE,Tyneway D,Patterson K.Decreased adenosinetriphosphatase activityin the absence of adrenocorticosteroids[J].Arch Otolaryngol Head Neck Surg,1989,115:817.
16 Lohuis PJFM,ten Cate WJF,Patterson KE,et al.Modula-tion of the rat stria vascularisin the absence of circulation ad-renocorticosteroids[J].Acta Otolaryngol(Stockh),1990,110:348.
17 Rarey KE,Lohuis PJFM,ten Cate WJF.Response of thestria vascularis to corticosteroids[J].Laryngoscope,1991,101:1 081.
18 ten Cate WJF,Curtis LM,Rarey KE.Effects of low-sodi-um,high-potassium dietary intake on cochlear lateral wallNa+,K(+)-ATPase[J].Eur Arch Otorhinolaryngol,1994,251:6.