轻度老年性痴呆患者听功能与神经心理量表测评的关系

The Relationships between Auditory Abilities and Outcomes of Neuropsychological Questionnaires in Patients with Alzheimer's Disease

宋鹏龙;王辉;李丽;张娟;付欣;李金兰;张明霞;孔峰;董会卿;王宁宇;

1:首都医科大学附属北京朝阳医院耳鼻咽喉-头颈外科

2:首都医科大学宣武医院耳鼻咽喉-头颈外科

3:首都医科大学宣武医院神经内科

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摘要

目的探讨轻度老年性痴呆(Alzhei mer’s disease,AD)患者听功能与神经心理量表测评的关系。方法测试50例正常老年人(对照组)和15例轻度AD患者(AD组)的周围听觉功能(纯音听阈、言语识别率)以及中枢听觉功能(同侧竞争信息-合成句识别试验、对侧竞争信息-合成句识别试验、交错扬扬格词试验、掩蔽级差试验),将各项神经心理量表分为言语相关性和非言语相关性两部分进行测评,分析测听结果和量表得分,比较听觉功能和神经心理量表结果之间的关系。结果AD患者周围听觉功能(纯音听阈、言语识别率)同言语相关性认知量表的关系(Kendall’s tau b分别为-0.33和0.44)比其与非言语相关性认知量表的关系(Kendall’s tau b分别为-0.23和0.26)更明显(P<0.05),对照组中无此现象。轻度AD患者中枢听觉功能(同侧竞争信息-合成句识别试验、对侧竞争信息-合成句识别试验、交错扬扬格词试验、掩蔽级差试验)与言语相关性和非言语相关性认知量表均有明显相关性(Kendall’s tau b范围0.370.56),与周围听功能与言语相关性和非言语相关性认知量表关系相比较,差异有统计学意义(P<0.05)。结论轻度AD患者的周围听功能障碍与言语相关性认知量表测评结果有关,其中枢听功能障碍与言语相关性和非言语相关性认知量表测评结果均有关,应用神经心理学量表测评轻度AD患者认知功能时,应注意听功能障碍对其结果的影响。

关键词

老年性痴呆;听功能障碍;神经心理量表;言语

基金项目(Foundation):

北京市科技计划项目研发攻关类(NO.Z080507030808018)

作者

宋鹏龙;王辉;李丽;张娟;付欣;李金兰;张明霞;孔峰;董会卿;王宁宇;

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老年性痴呆听功能障碍神经心理量表言语

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宋鹏龙王辉李丽张娟付欣李金兰张明霞孔峰董会卿王宁宇