外毛细胞基底侧膜动力蛋白分布均一性的研究
The Distribution of Prestin on the Whole Basolateral Surface of Outer Hair Cells
于宁;翟所强;赵红波;
1:解放军总医院耳鼻咽喉-头颈外科解放军耳鼻咽喉科研究所
2:美国肯塔基州立大学医学中心耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1Brownell WE,Bader CR,Bertrand D,et al.Evoked mechanical responses of isolated cochlear outer hair cells[J].Science,1985,227:194.
2Dallos P.The active cochlea[J].J Neurosci,1992,12:4575.
3Zheng J,Shen W,He DZ,et al.Prestinis the motor protein of cochlear outer hair cells[J].Nature,2000,405:149.
4Belyantseva I A,Adler HJ,Curi R,et al.Expression and lo-calization of prestin and the sugar transporter GLUT-5dur-ing development of electromotility in cochlear outer hair cells[J].J Neurosci,2000,20:116.
5Zheng J,Long KB,Shen W,et al.Prestin topology:localiza-tion of protein epitopesin relationtothe plasma membrane[J].Neuroreport,2001,12:1929.
6Dallos P,Evans BN,Hall worth R.Nature of the motor ele-ment in electrokinetic shape changes of cochlear outer hair cells[J].Nature,1991,350:155.
7Kalinec F,Holley MC,Iwasa K,et al.A membrane-based force generation mechanismin auditory sensory cells[J].Proc Natl Acad Sci USA,1992,89:8671.
8Hall worth R,Evans BN,Dallos P.The location and mecha-nism of electromotilityin guinea pig outer hair cells[J].J Neu-rophysiol,1993,70:549.
9Huang G,Santos-Sacchi J.Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation[J].Biophys J,1993,65:2228.
10Adler HJ,Belyantseva IA,Merritt RC Jr,et al.Expression of prestin,a membrane motor protein,in the mammalian auditory and vestibular periphery[J].Hear Res,2003,184:27.
11Zheng J,Du GG,Matsuda K,et al.The C-terminus of prestin influences nonlinear capacitance and plasma mem-brane targeting[J].J Cell Sci,2005,118:2987.
12Flock A,Flock B,Ulfendahl M.Mechanisms of movement in outer hair cells and a possible structural basis[J].Arch Otorhinolaryngol,1986,243:83.
13Forge A.Structural features of thelateral wallsin mammalian co-chlear outer hair cells[J].Cell Tissue Res,1991,265:473.
14Forge A,Zajic G,Li L,et al.Structural variability of the subsurface cisternae inintact,isolated outer hair cells shown by fluorescent labeling of intracellular membranes and freeze-fracture[J].Hear Res,1993,64:175.
15Holley MC,Ashmore JF.Spectrin,actin andthe structure of the cortical latticein mammalian cochlear outer hair cells[J].J Cell Sci,1990,96:283.
16Saito K.Fine structure of the sensory epithelium of guinea pig organ of corti:subsurface cisternae andlamellar bodiesin the outer hair cells[J].Cell Tissue Res,1983,229:467.
17Holley MC,Kalinec F,Kachar B.Structure of the cortical cytoskeletonin mammalian outer hair cells[J].J Cell Sci,1992,102:569.
18Oghalai JS,Patel AA,Nakagawa T,et al.Fluorescent-im-aged microdeformation of the outer hair cell lateral wall[J].J Neurosci,1998,18:48.
19Huang GJ,Santos-Sacchi J.Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane[J].Proc Natl Acad Sci USA,1994,91:12268.
20Santos-Sacchi J,Zhao HB.Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor pro-tein prestin and betrays its lateral mobility[J].Pflugers Arch,2003,446:617.
21Oghalai JS,Zhao HB,Kutz J W,et al.Voltage-andtension-dependent lipid mobilityin the outer hair cell plasma mem-brane[J].Science,2000,287:658.
22Yu N,Zhu ML,Zhao HB.Long-term usage of salicylate upregulates prestin expression in the guinea pig cochlea[J].Cell Mol Life Sci,2008,65:2407.
23Brownell WE,Spector AA,Raphael RM,et al.Micro-and nanomechanics of the cochlear outer hair cell[J].Ann Rev Biomed Eng,2001,3:169.