噪声习服对耳蜗外毛细胞生理特性的影响

The Influence of Long-Term Sound Conditioning on the Physiology of Outer Hair Cells

彭建华;陈建福;黄治物;

1:武汉大学人民医院耳鼻咽喉-头颈外科

2:温州医学院附属第一医院耳鼻咽喉科

摘要
目的观察噪声习服对正常清醒豚鼠耳蜗外毛细胞生理特性的影响。方法采用90dB(A)的宽带噪声对20只健康豚鼠进行连续14天的习服暴露,每天暴露8小时。分别于暴露前、暴露14天和暴露停止后7天及暴露停止后14天测试豚鼠DPOAE听力图(DP-gram)及1~8kHz各频率的输入/输出(I/O)函数曲线。结果DP-gram的测试结果显示噪声习服暴露使豚鼠低频段(1~3kHz)DPOAE的幅值升高,其中2及3kHz升高最为明显,分别为5.0及7.5dB(P<0.05);使高频段(4~8kHz)DPOAE幅值出现轻度降低。在I/O曲线的测试结果中,噪声习服暴露使低频(1~3kHz)高强度段(50~70dBSPL)DPOAE的幅值升高,高频段(4~8kHz)幅值轻度下降,在噪声暴露停止后14天又逐渐恢复正常。结论噪声习服暴露可以使豚鼠耳蜗外毛细胞低频段的主动性增强。
关键词
噪声习服;畸变产物耳声发射;外毛细胞;噪声性聋
基金项目(Foundation):
作者
彭建华;陈建福;黄治物;
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