1Eckel man BP,Salvesen GS,Scott FL.Human inhibitor of a-poptosis proteins:why XI APis the black sheep of the family[J].EMBO Reports,2006,7:988.

2Rybak LP,Whitworth CA,Mukherjea D,et al.Mechanisms of cisplatin-induced ototoxicity and prevention[J].Hearing Re-search,2007,226:157.

3Crook NE,Clem RJ,Miller LK.An apoptosis-inhibiting bacu-lovirus gene with a zinc finger-like motif[J].Journal of Virol-ogy,1993,67:2168.

4Kominsky DJ,Bickel RJ,Tyler KL.Reovirus-induced apopto-sis requires mitochondrial release of Smac/DI ABLO and in-volves reduction of cellular inhibitor of apoptosis proteinlevels[J].Journal of Virology,2002,76:11414.

5Srinivasula SM,Hegde R,Saleh A,et al.Aconserved XI AP-interaction motif in caspase-9and Smac/DI ABLO regulates caspase activity and apoptosis[J].Nature,2001,410:112.

6Srinivasula SM,Heged R,Saleh A,et al.Aconserved XI AP-interaction motif in caspase-9and Smac/DI ABLO regulates caspase activity and apoptosis[J].Nature,2001,410:112.

7Huang Y,Park YC,Rich RL,et al.Structural basis of caspase inhibition by XI AP:differential roles of the linker versus the BIR domain[J].Cell,2001,104:781.

8Riedl SJ,Renatus M,Schwarzenbacher R,et al.Structural basisfor theinhibition of caspase-3by XIAP[J].Cell,2001,104:791.

9Suzuki Y,Nakabayashi Y,Nakata K,et al.X-linkedinhibitor of apoptosis protein(XI AP)inhibits caspase-3and-7in distinct modes[J].Biological Chemistry,2001,276:27058.

10Yang Y,Fang S,Jensen JP,et al.Ubiquitin proteinligase ac-tivity of I APs and their degradation in proteasomes in re-sponse to apoptotic stimuli[J].Science,2000,288:874.

11Suzuki Y,Nakabayashi Y,Takahashi R.Ubiquitin-protein ligase activity of X-linkedinhibitor of apoptosis protein pro-motes proteasomal degradation of caspase-3and enhancesits anti-apoptotic effect in Fas-induced cell death[J].Pro-ceedings of the National Academy of Sciences of the United States of America,2001,98:8662.

12Hofer-Warbinek R,Schmid JA,Stehlik C,et al.Activation of NF-kappa B by XI AP,the Xchromosome-linkedinhibi-tor of apoptosis,in endothelial cells involves TAK1[J].Bio-logical Chemistry,2000,275:22064.

13Sanna MG,da Silva Correia J,Ducrey O,et al.I AP suppres-sion of apoptosis involves distinct mechanisms:the TAK1/JNK1signaling cascade and caspase inhibition[J].Molecular&Cellular Biology,2002,22:1754.

14Lewis J,Burstein E,Reffey SB,et al.Uncoupling of the sig-naling and caspase-inhibitory properties of X-linkedinhibi-tor of apoptosis[J].Biological Chemistry,2004,279:9023.

15Jordan BW,Dinev D,Le Mellay V,et al.Neurotrophin recep-tor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death[J].Biological Chemistry,2001,276:39985.

16Yamagi wa Y,Marienfeld C,Meng F,et al.Translational reg-ulation of x-linkedinhibitor of apoptosis protein byinterleu-kin-6:a novel mechanismof tumor cell survival[J].CancerResearch,2004,64:1293.

17Zou T,Rao JN,Guo X,et al.NF-kappaB-mediated I AP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion[J].American Journal of Physiology-Cell Physiology,2004,286:C1009.

18Liston P,Fong WG,Kelly NL,et al.Identification of XAF1as an antagonist of XI AP anti-Caspase activity[J].Nature Cell Biology,2001,3:128.

19Srinivasula SM,Gupta S,Datta P,et al.Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2[J].Biological Chemistry,2003,278:31469.

20Sergi B,Ferraresi A,Troiani D,et al.Cisplatin ototoxicity in the guinea pig:vestibular and cochlear damage[J].Hear Res,2003,182:56.

21Laurell G,Teixeira M,Sterkers O,et al.Effect of cisplatin administration on the electrochemical composition of endo-lymphin the rat cochlea[J].Hear Res,1995,87:16.

22Komune S,Matsuda K,Nakagawa T,et al.Disturbance of regulation of sodium by cis-diamminedichloroplatinum in perilymph of the guinea pig cochlea[J].Ann Otol Rhinol Lar-yngol,1995,104:149.

23Walker EMJr,Fazekas-May MA,Bowen WR.Nephrotoxic and ototoxic agents[J].Clinics in Laboratory Medicine,1990,10:323.

24Dehne N,Lautermann J,Petrat F,et al.Cisplatin ototoxicity:involvement of iron and enhancedformation of superoxide ani-on radicals[J].Toxicol Appl Pharmacol,2001,174:27.

25Kang S,Zeng Z,Shi X.Effect of electroacupuncture on succi-nate dehydrogenase of gentamycin induced ototoxic cochlear hair cells in guinea pigs[J].Chinese Journal of Integrated Traditional and Western Medicine,1998,18:362.

26Tsukasaki N,Whitworth CA,Rybak LP.Acute changesincochle-ar potentials due to cisplatin[J].Hearing research,2000,149:189.

27Mostafapour SP,Del Puerto NM,Rubel EW.Bcl-2Overex-pression eliminates deprivation-induced cell death of brain-stemauditory neurons[J].Neurosci,2002,22:4670.

28Cregan SP,MacLaurin JG,Craig CG,et al.Bax-dependent caspase-3activation is a key determinant in p53-induced apoptosis in neurons[J].Neurosci,1999,19:7860.

29AlamSA,Ikeda K,Oshima T,et al.Cisplatin-induced apop-totic cell deathin Mongolian gerbil cochlea[J].Hearing Re-search,2000,141:28.

30Tong QS,Zheng LD,Wang L,et al.Downregulation of XI AP expression induces apoptosis and enhances chemotherapeutic sensitivityin human gastric cancer cells[J].Cancer Gene T-her,2005,12:509.

31Fraser M,Leung BM,Yan X,et al.P53is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated che-moresistance in human ovarian cancer cells[J].Cancer Res,2003,63:7081.

32Qin LF,Ng IO.Induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells[J].Cancer Lett,2002,175:27.

33Pirvola U,Xing-Qun L,Virkkala J,et al.Rescue of hearing,auditory hair cells,and neurons by CEP-1347/KT7515,an inhibitor of c-Jun N-terminal kinase activation[J].Neuros-ci,2000,20:43.

34Wang J,Ladrech S,Pujol R,et al.Caspaseinhibitors,but not c-Jun NH2-terminal kinaseinhibitor treatment,prevent cisplatin-induced hearingloss[J].Cancer Res,2004,64,9217.

35Watanabe K,Jinnouchi K,Yagi T.Detection of single-stranded DNA(ssDNA)in the vestibule of guinea pigs after the application of cisplatinum(CDDP)[J].Anticancer Res,2001,21:1135.

36Devarajan P,Savoca M,Castaneda MP,et al.Cisplatin-in-duced apoptosis in auditory cells:role of death receptor and mitochondrial pathways[J].Hear Res,2002,174:45.

37Zhang M,Liu W,Ding D,et al.Pifithrin-alpha suppresses p53and protects cochlear and vestibular hair cells fromcispla-tin-induced apoptosis[J].Neuroscience,2003,120:191.

38Checinska A,Hoogeland BS,Rodriguez JA,et al.Role of XI-APin inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells:a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3activation[J].Exp Cell Res,2007,313:1215.

39Dasgupta P,Kinkade R,Joshi B,et al.Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin[J].Proc Natl Acad Sci USA,2006,103:63327.

40KimJS,Lee J M,Chwae YJ,et al.Cisplatin-induced apopto-sis in Hep3Bcells:mitochondria-dependent andindependent pathways[J].Biochem Pharmacol,2004,67:1459.

41Takaoka S,Iwase M,Uchida M,et al.Effect of combining ep-idermal growthfactor receptor inhibitors and cisplatin on pro-liferation and apoptosis of oral squamous cell carcinoma cells[J].Int J Oncol,2007,30:1469.

42Matsumiya T,Imaizumi T,Yoshida H,et al.Cisplatin inhib-its the expression of X-chromosome-linkedinhibitor of ap-optosis proteinin an oral carcinoma cell line[J].Oral Oncol,2001,37:296.

43Gordon GJ,Mani M,Mukhopadhyay L,et al.Inhibitor of apopto-sis proteins are regulated bytumour necrosisfactor-alphain ma-lignant pleural mesothelioma[J].Pathol,2007,211:439.

44Gordon GJ,Mani M,Mukhopadhyay L,et al.Expression pat-terns of inhibitor of apoptosis proteins in malignant pleural mesothelioma[J].Pathol,2007,211:447.

45Nomura T,Mimata H,Yamasaki M,et al.Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells[J].Urol Oncol,2004,22:453.

46Sun H,Nikolovska-Coleska Z,Yang CY,et al.Structure-based design,synthesis,and evaluation of conformationally constrained mimetics of the second mitochondria-derived ac-tivator of caspase that target the X-linkedinhibitor of apop-tosis protein/caspase-9interaction site[J].Med Chem,2004,47:4147.

47Andjilani M,Droz JP,Benahmed M,et al.Down-regulation of FAKand IAPs by laminin during cisplatin-induced apoptosis in testicular germcell tumors[J].Int J Oncol,2006,28:535.

48Yang X,Xing H,Gao Q,et al.Regulation of HtrA2/Omi by X-linkedinhibitor of apoptosis proteinin chemoresistance in human ovarian cancer cells[J].Gynecol Oncol,2005,97:413.

49Cooper LB,Chan DK,Roediger FC,et al.AAV-mediated delivery of the caspaseinhibitor XI AP protects against cispla-tin ototoxicity[J].Otol Neurotol,2006,27:484.