钙通道阻滞药与噪声对豚鼠耳蜗功能的交互作用
Interaction of Calcium Channel Blocker and Noise on the Cochlear Functions in Guinea Pigs
刘军;于宁;张永强;李兴启;
1:解放军总医院耳鼻咽喉-头颈外科解放军总医院耳鼻咽喉科研究所
2:解放军总医院耳鼻咽喉-头颈外科解放军总医院耳鼻咽喉科研究所
3:吉林省延边眼耳鼻喉科医院耳鼻喉科
4:解放军总医院耳鼻咽喉-头颈外科解放军总医院耳鼻咽喉科研究所 北京100853
摘要关键词基金项目(Foundation):作者参考文献1Fridberger A,Flock A,Ulfendahl M,et al.Acoustic oversti m-ulationincreases outer hair cell Ca2+concentrations and causes dynamic contractions of the hearing organ[J].Proc Natl Acad Sci USA,1998,95:7127.
2Fridberger A,Ulfendahl M.Acute mechanical oversti mulation of isolated outer hair cells causes changes inintracellular calci-umlevels without shape changes[J].Acta Otolaryngol,1996,116:17.
3Han DY,Harada N,Tomoda K,et al.Characterization of the calciuminfluxinduced by depolarization of guinea pig cochlear spiral ganglion cells[J].ORL J Otorhinolaryngol Relat Spec,1994,56:125.
4刘军,于宁,韩东一,等.钙泵间接激活剂对噪声性聋的保护作用[J].中华耳鼻咽喉科杂志2002,37:425.
5李兴启,于宁,孙建和.尼福地平对噪声性听力损失拮抗作用的实验观察[J].中华医学杂志,2000,80:951.
6刘军,孙勍,韩冰,等.尼福地平对豚鼠耳蜗功能和噪声性听力损失的影响[J].中国耳鼻咽喉头颈外科,2006,13:232.
7Ikeda K,Kusakari J,Takasaka T,et al.Ionic change in co-chlear endolymph of the guinea pig induced by acoustic injury[J].Hear Res,1988,32:103.
8Bobbin RP,Jastreboff PJ,Fallon M,et al.Ni modipine,an L-channel Ca2+antagonist,reverses the negative summating potential recorded fromthe guinea pig cochlea[J].Hear Res,1990,46:277.
9刘军,张宝明,谭祖林,等.L-型钙通道阻滞药尼福地平对耳蜗功能的影响[J].听力学及言语疾病杂志,2004,12:321.
10刘军,韩梅,于宁,等.钙通道阻滞药对耳蜗微音电位输入/输出函数曲线的影响[J].听力学及言语疾病杂志,2003,11:35.
11Li W,Zhao L,Jiang S,et al.Effects of high intensity i m-pulse noise on ionic concentrations in cochlear endolymph of the guinea pig[J].Chinese Med J(English),1997,110:883.
12Maurer J,Heinrich UR,Hinni M,et al.Alteration of the calciumcontent ininner hair cells of the cochlea of the guinea pig after acute noise trauma with and without application of the organic calciumchannel blocker diltiazem[J].ORLJ Oto-rhinolaryngol Relat Spec,1999,61:328.
13Juhu AF,Santos-Sacchi JR.Physiology of Ear[M].New York:Raven Press,1988.385～406.
14Barnes S,Davies JA.The effects of calciumchannel agonists and antagonists on the release of endogenous glutanate from cerebeillar slices[J].Neurosci Lett,1988,92:58.
15LePage EL.Functional role of the olivo-cochlear bundle:a motor unit control system in the mammalian cochlea[J].Hear Res,1989,38:177.
16Chan DK,Hudspeth AJ.Ca2+current-driven nonlinear am-plification by the mammalian cochlea in vitro[J].Nat Neu-rosci,2005,8:149.
17McFadden SL,Zheng XY,Ding DL.Conditioning-induced protection fromi mpulse noise in female and male chinchillas[J].J Acoust Soc Am,2000,107:2162.
18Ryan AF,Bennett TM,Woolf NK,et al.Protection from noise-induced hearing loss by prior exposure to a nontrau-matic sti mulus:role of the middle ear muscles[J].Hear Res,1994,72:23.