海藻酸钠地塞米松凝胶圆窗给药后外淋巴液中地塞米松浓度的变化

Study the Pharmacokinetics of Dexamethasone in the Perilymph after the Sodium Alginate Dexamethasone Gel Transtympanic Administration in Vivo

顾志敏;杨军;吴皓;

1:上海交通大学新华医院耳鼻咽喉一头颈外科

2:上海交通大学新华医院耳鼻咽喉一头颈外科

3:上海交通大学新华医院耳鼻咽喉一头颈外科上海200092

4:上海200092

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摘要

目的分析海藻酸钠地塞米松凝胶(Alg-Dex凝胶)经圆窗给药后地塞米松在外淋巴液中的浓度变化。方法健康豚鼠30只随机分成5组,每组6只,于每只豚鼠单侧(右耳)经圆窗给海藻酸钠地塞米松凝胶(45mg/ml)20μl后的1、2、3、4、5天分别用高压液相色谱仪分析外淋巴液中的地塞米松浓度。结果在Alg-Dex凝胶给药后1、2、3、4、5天在外淋巴液中均能检测到地塞米松,浓度分别为0.49±0.06、1.32±0.28、0.65±0.08、0.66±0.05、0.53±0.17mg/L,其中第2天浓度最高(1.32±0.28mg/L),第3～5天药物浓度较稳定,平均浓度为0.61±0.07mg/L。结论海藻酸钠能作为地塞米松良好的缓释载体,使其缓慢、持续地经圆窗膜渗透到外淋巴液中。

关键词

海藻酸钠;地塞米松;圆窗;外淋巴液;高压液相色谱仪

基金项目(Foundation):

上海市科委基金资助项目(No:0341l9819)

作者

顾志敏;杨军;吴皓;

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海藻酸钠地塞米松圆窗外淋巴液高压液相色谱仪

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顾志敏杨军吴皓