前庭代偿过程中GABAA受体α1亚型在前庭内侧核中的变化
The Change of GABAA receptor α1 Subunit in the Medial Vestibular Nucleus following Unilateral Labyrinthectomy
邹宇;孔维佳;刘波;
1:广州医学院附属广州儿童医院耳鼻咽喉科
2:华中科技大学同济医学院附属协和医院耳鼻咽喉科
3:华中科技大学同济医学院附属协和医院耳鼻咽喉科 (广州510120)





1关新民,主编.医学神经生物学[M].北京:人民卫生出版社,2002.90~95.
2Mathieu B,Mohammed H,Erwin I.Long term plasticity of ipsilesional vestibular nucleus neurons after unilateral laby-rinthectomy[J].J Neurophysiol,2003,90:184.
3Babalian A,Vibert N,Assie G.Central vestibular networks:Functional characterizationin the isolated,in vitro whole brain of guinea pig[J].Neurosicence,1997,81:405.
4Bamard EA,Skolnick P,Olsen RW,et al.International U-nion of Phamacology.XV.Subtypes ofγ-aminobutyric acid A receptors:classification on the basis of subunit structure and receptor function[J].Phamacol Rev,1998,50:291.
5Fritschy J M,Brunig I.Formation and plasticity of GABAergic synapses:physiological mechanisms and pathophysiological im-plications[J].Pharmacology&Therapeutics,2003,98:299.
6Magnusson AK,Lindstrom S,Tham R.GABAB receptor contribute to vestibular compensation after unilateral laby-rinthectomy in pigmented rats[J].Exp Brain Res,2000,134:32.
7Horii A,Masumura C,Smith PF,et al.Microarray analysis of gene expression in the rat vestibular nucleus complex fol-lowing unilateral vestibular deafferentation[J].Neurochem,2004,91:975.
8Horii A,Kitahara T,Smith PF,et al.Effects of unilateral labyrinthectomy on GAD,GAT1,and GABA receptor gene expressionin the rat vestibular nucleus[J].Neuro Report,2003,14:2359.
9Eleore L,Vassias I,Bernat I,et al.An in situ hydridization andimmunofluorescence study of GABAAand GABAB recep-tors in the vestibular nuclei of the intact and unilaterally laby-rinthectomized rat[J].Exp Brain Res,2005,160:166.
10Tighilet B,Lacour M.Gamma amino butyric acid(GABA)immunoreactivity in the vestibular nuclei of normal and uni-lateral vestibular neurectomized cats[J].Eur J Neurosci,2001,13:2255.