氯化物协同转运蛋白KCC2在正常大鼠内耳中的表达及意义
Significance and Expression of Cation-chloride Contransporter KCC2 in the Rat Cochlea
章晓军;黄治物;杨琨;肖伯奎;黄娟;
1:武汉大学人民医院耳鼻咽喉-头颈外科
2:武汉大学人民医院耳鼻咽喉-头颈外科
3:武汉大学人民医院耳鼻咽喉-头颈外科
4:武汉大学人民医院耳鼻咽喉-头颈外科
摘要关键词基金项目(Foundation):作者参考文献1黄治物,陈平,吴展元,等.耳鸣电生理学实验性研究[J].中国病理生理杂志,2005,21:642.
2Huang ZW,Luo YY,Wu ZY,et al.Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate[J].Neurophysiol,2005,93:2053.
3Oliver D,He DZ,Klocker N,et al.Intracellular anions as the voltage sensor of prestin,the outer hair cell motor protein[J].Science,2001,292:2340.
4Chudotvorova I,Ivanov A,Rama S,et al.Early expression of KCC2in rat hippocampal cultures augments expression of functional GABAsynapses[J].Physiol,2005,566:671.
5Lu J,Karadsheh M,Delpire E.Developmental regulation of the neuronal-specificisoformof K-Cl cotransporter KCC2in postnatal rat brains[J].Neurobiol,1999,39:558.
6Di Fulvio M,Lincoln TM,Lauf PK,et al.Protein kinase G regulates potassiumchloride cotransporter-4[corrected]ex-pression in primary cultures of rat vascular smooth muscle cells[J].Biol Chem,2001,276:21046.
7Gillen CM,Brill S,Payne JA,et al.Molecular cloning and functional expression of the K-Cl cotransporter fromrabbit,rat,and human.A new member of the cation-chloride co-transporter family[J].Biol Chem,1996,271:16237.
8Zhang LL,Fina ME,Vardi N.Regulation of KCC2and NKCC during development:membrane insertion and differences be-tween cell types[J].Comp Neurol,2006,499:132.
9Qu C,Liang F,Hu W,et al.Expression of CLC-Kchloride channels in the rat cochlea[J].Hear Res,2006,213:79.
10Sakaguchi N,Crouch JJ,Lytle C,et al.Na-K-Cl cotrans-porter expressionin the developing and senescent gerbil coch-lea[J].Hear Res,1998,118:114
11吴振恭,褚汉启,黄孝文,等.Na-K-2Cl联合转运子1在小鼠耳蜗侧壁组织中的表达及意义[J].听力学及言语疾病杂志,2007,15:44.
12Takeuchi S,Ando M,Kozakura K,et al.Ion channelsin ba-solateral membrane of marginal cells dissociated from gerbil stria vascularis[J].Hear Res,1995,83:89.
13Sauer G,Richter CP,Klinke R.Sodium,potassium,chloride and calciumconcentrations measuredin pigeon perilymph and endolymph.[J].Hear Res,1999,129:1.
14Wangemann P,Liu J,Marcus DC.Ion transport mechanisms responsible for K+secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro[J].Hear Res,1995,84:19.
15Crouch JJ,Sakaguchi N,Lytle C,et al.Immunohistochemical localization of the Na-K-Cl cotransporter(NKCC1)in the gerbil inner ear[J].Histochem Cytochem,1997,45:773