MARK4基因在小鼠的表达研究及其在DFNA4基因搜寻中的意义
Expression of MARK4 Gene in Mouse Cochlea and as Candidate Gene for the Hearing Loss Locus, DFNA4
纵亮;王秋菊;郭维维;韩明鲲;兰兰;赵翠;韩东一;
1:解放军总医院耳鼻咽喉-头颈外科 解放军耳鼻咽喉科研究所
2:解放军总医院第一附属医院耳鼻咽喉-头颈外科
3:解放军总医院耳鼻咽喉-头颈外科
4:解放军耳鼻咽喉科研究所
摘要关键词基金项目(Foundation):作者参考文献1 Beghini A,Magnani I,Roversi G,et al.The neural progenitor-restrictedisoformof the MARK4genein19q13.2is upregu-latedin human gliomas and overexpressed in a subset of glio-blastoma cell lines[J].Oncogene,2003,22:2581.
2 郭运凯,谢鼎华.小鼠内耳毛细胞基因及其功能[J].国外医学耳鼻咽喉科学分册,2004,28:340.
3 宇雅苹,杨仕明.小鼠内耳发育的分子生物学研究进展[J].听力学及言语疾病杂志,2006,14:386.
4 Kato T,Satoh S,Okabe H,et al.Isolation of a novel human gene,MARK1,homologous to MARK3anditsinvolvement in hepatocellular carcinogenesis[J].Neoplasia,2001,3:4.
5 Lizcano J M,Goransson O,Toth R,et al.LKB1is a master ki-nase that activates13kinases of the AMPK subfamily,inclu-ding MARK/PAR-1[J].EMBOJ,2004,23:833.
6 Trinczek B,Brajenovic M,Ebneth A,et al.MARK4is a novel microtubule-associated proteins/microtubule affinity-regu-lating kinase that binds tothe cellular microtubule network and to centrosomes[J].J Biol Chem,2004,279:5915.
7 Chen AH,Ni L,Fukushi ma K,et al.Linkage of a gene for dominant non-syndromic deafness to chromosome19[J].Hum Mol Genet,1995,4:1073.
8 Mirghomizadeh F,Bardtke B,Devoto M,et al.Secondfamily with hearing i mpairment linked to19q13and refined DFNA4localisation[J].Eur J Hum Genet,2002,10:95.
9 Donaudy F,Snoeckx R,Pfister M,et al.Nonmuscle myosin heavy-chain gene MYH14is expressed in cochlea and muta-tedin patients affected by autosomal dominant hearingi mpair-ment(DFNA4)[J].AmJ Hum Genet,2004,74:770.
10 Yang T,Pfister M,Blin N,et al.Genetic Heterogeneity of Deafness Phenotypes Linked to DFNA4[J].AmJ Hum Gen-et,2005,139A:9.