BMP/Smad信号通路对内耳发育影响的研究进展
邓安春;杨仕明;黄德亮;
1:解放军总医院耳鼻咽喉头颈外科解放军耳鼻咽喉研究所
2:解放军总医院耳鼻咽喉头颈外科解放军耳鼻咽喉研究所
3:解放军总医院耳鼻咽喉头颈外科解放军耳鼻咽喉研究所 (北京100853)现在第三军医大学附属新桥医院耳鼻咽喉科
4:(北京100853)
1 Granjeiro J M,Oliveira RC,Bustos-Valenzuela JC,et al.Bone morphogenetic proteins:from structure to clinical use[J].Braz J Med Biol Res,2005,38:1463.
2 Constam DB,Robertson EJ.Regulation of bone morphogenet-ic protein activity by pro domains and proprotein convertases[J].J Cell Biol,1999,144:139.
3 Tsumaki N,Yoshikawa H.The role of bone morphogenetic proteins in endochondral bone formation[J].Cytokine Growth Factor Rev,2005,16:279.
4 Von Bubnoff A,Cho KW.Intracellular BMPsignaling regula-tionin vertebrates:pathway or network[J].Dev Biol,2001,239:1.
5 杨宁,陈增海,栾怡,等.骨形态发生蛋白的研究进展[J].山东大学学报(医学版,2004,42:244.
6 Zhao GQ.Consequences of knocking out BMP signalingin the mouse[J].Genesis,2003,35:43.
7 Attisano L,Tuen Lee-Hoeflich S.The Smads[J].Genome Biol,2001,2(S3010):1.
8 Miyazono K,Kusanagi K,Inoue H.Divergence and conver-gence of TGF-beta/BMPsignaling[J].J Cell Physiol,2001,187:265.
9 Itoh S,Itoh F,Goumans MJ,et al.Signaling of transforming growth factor-beta family members through Smad proteins[J].Eur J Biochem,2000,267:6954.
10 Nakao A,Afrakhte M,Moren A,et al.Identification of Smad7,a TGFbeta-inducible antagonist of TGF-beta sig-nalling[J].Nature,1997,389:631.
11 Imamura T,Takase M,Nishihara A,et al.Smad6inhibits sig-nalling by the TGF-beta superfamily[J].Nature,1997,389:622.
12 Massague J.TGF-beta signal transduction[J].Annu Rev Biochem,1998,67:753.
13 Luukko K,Ylikorkala A,Makela TP.Developmentallyregulated expression of Smad3,Smad4,Smad6,and Smad7involved in TGF-beta signaling[J].Mech Dev,2001,101:209.
14 Flanders KC,Ki m ES,Roberts AB.I mmunohistochemical expression of Smads1-6in the15-day gestation mouse embryo:signaling by BMPs and TGF-betas[J].Dev Dyn,2001,220:141.
15 Moustakas A,Heldin CH.From mono-tooligo-Smads:the heart of the matterin TGF-beta signal transduction[J].Genes Dev,2002,16:1867.
16 Sakou T.Bone morphogenetic proteins:frombasic studies to clinical approaches[J].Bone,1998,22:591.
17 Guicheux J,Lemonnier J,Ghayor C,et al.Activation of p38mitogen-activated protein kinase and c-Jun-NH2-ter-minal kinase by BMP-2andtheir i mplicationinthe sti mula-tion of osteoblastic cell differentiation[J].J Bone Miner Res,2003,18:2060.
18 Reilly GC,Golden EB,Grasso-Knight G,et al.Differential effects of ERKand p38signaling in BMP-2sti mulated hy-pertrophy of cultured chick sternal chondrocytes[J].Cell Commun Signal,2005,3:3.
19 Derynck R,Zhang YE.Smad-dependent and Smad-inde-pendent pathways in TGF-beta family signalling[J].Na-ture,2003,425:577.
20 张继帅,谭晓红,王友亮,等.Cre重组酶在软骨组织特异性转基因小鼠中表达的时空分布[J].军事医学科学院院刊,2004,28:509.
21 Yang X,Li C,Herrera PL,et al.Generation of Smad4/Dpc4conditional knockout mice[J].Genesis,2002,32:80.
22 Capdevila J,Izpisua Bel monte JC.Patterning mechanisms controlling vertebrate li mb development[J].Annu Rev Cell Dev Biol,2001,17:87.
23 Karsenty G,Wagner EF.Reaching a genetic and molecular un-derstanding of skeletal development[J].Dev Cell,2002,2:389.
24 Beppu H,Kawabata M,Hamamoto T,et al.BMP type II receptor is requiredfor gastrulation and early development of mouse embryos[J].Dev Biol,2000,221:249.
25 Cao X,Chen D.The BMP signaling andin vivo bone forma-tion[J].Gene,2005,357:1.
26 Morsli H,Choo D,Ryan A,et al.Development of the mouse inner ear and origin of its sensory organs[J].J-Neu-rosci,1998,18:3327.
27 Brown ST,Martin K,Groves AK.Molecular basis of inner ear induction[J].Curr Top Dev Biol,2003,57:115.
28 Chang W,ten Dijke P,Wu DK.BMP pathways are involvedin otic capsule formation and epithelial-mesenchymal signaling in the developing chickeninner ear[J].Dev Biol,2002,251:380.
29 Goldstein AM,Brewer KC,Doyle AM,et al.BMP signalingis necessaryfor neural crest cell migration and ganglionformationin the enteric nervous system[J].Mech Dev,2005,122:821.
30 Hogan BL.Bmps:multifunctional regulators of mammalian em-bryonic development[J].Harvey Lect,1996-1997,92:83.
31 De Robertis EM,Kuroda H.Dorsal-ventral patterning and neural inductionin Xenopus embryos[J].Annu Rev Cell Dev Biol,2004,20:285.
32 Nakayama T,Cui Y,Christian JL.Regulation of BMP/Dpp signaling during embryonic development[J].Cell Mol Life Sci,2000,57:943.
33 Wijgerde M,Karp S,Mc Mahon J,et al.Noggin antagonism of BMP4signaling controls development of the axial skeleton in the mouse[J].Dev Biol,2005,286:149.
34 Gerlach LM,Hutson MR,Germiller JA,et al.Addition of the BMP4antagonist,noggin,disrupts avianinner ear devel-opment[J].Development,2000,127:45.
35 Chang W,Nunes FD,De Jesus-Escobar J M,et al.Ectopic noggin blocks sensory and nonsensory organ morphogenesis in the chickeninner ear[J].Dev Biol,1999,216:369.
36 Thompson DL,Gerlach-Bank LM,Barald KF,et al.Reti-noic acid repression of bone morphogenetic protein4ininner ear development[J].Mol Cell Biol,2003,23:2277.
37 Gerlach-Bank LM,Cleveland AR,Barald KF.DANdirects endolymphatic sac and duct outgrowthin the avian inner ear[J].Dev Dyn,2004,229:219.
38 Li HW,Corrales CE,Wang Z,et al.BMP4signaling is in-volvedin the generation of inner ear sensory epithelia[J].BMC Dev Biol,2005,5:16.
39 Liu W,Oh SH,Kang YY,et al.Bone morphogenetic pro-tein4(BMP4):a regulator of capsule chondrogenesis in the developing mouse inner ear[J].Dev Dyn,2003,226:427.
40 Blauwkamp MN,Beyer LA,Kabara L,et al.The role of bone morphogenetic protein4in inner ear development and function[J].Hear Res,2007,225:71.
41 Dunn NR,Winnier GE,Hargett LK,et al.Haploinsufficient phenotypes in BMP4heterozygous null mice and modification by mutationsin Gli3and Alx4[J].Dev Biol,1997,188:235.
42 Oxburgh L,Dudley AT,Godin RE,et al.BMP4substitutes for loss of BMP7during kidney development[J].Dev Biol,2005,286:637.
43 Fekete DM,Wu DK.Revisiting cell fate specification in the inner ear[J].Curr Opin Neurobiol,2002,12:35.
44 Blauwkamp MN,Beyer LA,Kabara L,et al.The role of bone morphogenetic protein4in inner ear development and function[J].Hear Res,2007,225:71.
45 Raft S,Nowotschin S,Liao J,et al.Suppression of neural fate and control of inner ear morphogenesis by Tbx1[J].De-velopment,2004,131:1801.
46 Tiveron MC,Pattyn A,Hirsch MR,et al.Role of Phox2b and Mash1in the generation of the vestibular efferent nucle-us[J].Dev Biol,2003,260:46.
47 Liu A,Niswander LA.Bone morphogenetic protein signal-ling and vertebrate nervous systemdevelopment[J].Nat Rev Neurosci,2005,6:945.
48 Pujades C,Kamaid A,Alsina B,et al.BMP-signalingregulates the generation of hair-cells[J].Dev Biol,2006,292:55.
49 Jones J M,Montcouquiol M,Dabdoub A,et al.Inhibitors of differentiation and DNA binding(Ids)regulate Math1and hair cell formation during the development of the organ of Corti[J].J Neurosci,2006,26:550.
50 Bermingham NA,Hassan BA,Price SD,et al.Math1:an essential gene for the generation of inner ear hair cells[J].Science,1999,284:1837.
51 Yang X,Castilla LH,Xu X,et al.Angiogenesis defects and mesenchymal apoptosisin micelacking SMAD5[J].Develop-ment,1999,126:1571.