EGCG对阿米卡星诱导的大鼠螺旋神经元凋亡的保护作用
The Protection of EGCG from Amikacin-induced Apoptosis of Spiral Ganglion Neurons in Rats
罗欣荣;谢鼎华;刘强和;
1:中南大学耳科研究所
2:桂林医学院附属医院耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1 Sha SH,Zajic G,Epstein CJ,et al.Overexpression of cop-per/zinc superoxide dismutase protects from Kanamycin-in-duced hearing loss[J].Audiol Neurootol,2001,6:117.
2刘国辉,谢鼎华,伍伟景.儿茶素对SD大鼠卡那霉素耳神经毒性保护作用的形态学研究[J].湖南医科大学学报,2002,27:503.
3 Xie D,Liu G,Zhu G,et al.(-)-Epigallocatechin-3-gal-late protects cultured spiral ganglion cells from H2O2-inducedoxidizing damage[J].Acta Otolaryngol,2004,124:464.
4 Alam SA,Ikeda K,Oshima T,et al.Cisplation-induced ap-optotic cell death in Mongolian gerbil cochlea[J].Hear Res,2000,141:28.
5 Gavrieli Y,Sherman Y,Ben-Sasson SA.Identification ofprogrammed cell death in situ via specific labeling of nuclearDNA fragmentation[J].J cell Biol,1992,119:493.
6 Lang H,Liu C.Apoptosis and hair cell degeneration in thevestibular sensory epithelia of the guinea pig following a genta-micin insult[J].Hear Res,1997,111:177.
7 Charriaut-Marlangue C,Ben-Ari Y.A Cautionary note onthe use of the TUNEL stain to determine apoptosis[J].Neu-roreport,1995,7:61.
8 Bicknell GR,Cohen GM.Cleavage of DNA to large Kilobasepair fragments occurs in some forms of necrosis as well as ap-optosis[J].Biochem Biophys Res Commun,1995,207:40.
9 Srinivas P,Gopinath G,Banerji A,et al.Plumbagin inducesreactive oxygen species,which mediate apoptosis in human cer-vical cancer cells[J].Mol Carcinog,2004,40:201.
10 Takahashi A,Masuda A,Sun M,et al.Oxidative stress-induced apoptosis is associated with alterations in mitochon-drial caspase activity and Bcl-2-dependent alteration in mi-tochondrial Ph(PHM)[J].Brain Res Bull,2004,15:497.
11 Buccellato LJ,Tso M,Akinci OI,et al.Reactive oxygenspecies are required for hyperoxia-induced Bax activationand cell death in alveolar epithelial cells[J].J Biol Chem,2004,20:6 753.
12 Simbula G,Pibiri M,Sanna L,et al.The Peroxisome prolif-erator BR931 Kills Fao cells by P53-dependent apoptosis[J].Life sci,2004 4:271.
13 Mc Fadden SL,Ding D,Jiang H,et al.Time course of effer-ent fiber and spiral ganglion cell degeneration following com-plete hair cell loss in chinchilla[J].Brain Res,2004,30:40.
14 Song BB,Anderson DJ,Schacht J.Protection from gentami-cin ototoxicity by iron chlelators in guinea pig in vivo[J].JPharmacol Exp Ther,1997,282:369.
15沙素华,高起学,李兴启,等.氨基甙类抗生素的耳毒性机理及其预防的新进展[J].听力学及言语疾病杂志,2001,9:180.
16 Chen L,Iee MJ,Li H,et al.Absorption,distribution,elimi-nation of tea polyphenols in rats[J].Drug Metab Dispos,1997,25:1 045.