分泌性中耳炎中耳积液中TGF-β_1检测的临床意义
Transforming Growth Factor β_1 in Secretory Otitis Media
李洁;赵守琴;刘华;王阳;
1:首都医科大学附属北京同仁医院耳鼻咽喉头颈外科教育部重点实验室(首都医科大学)
2:河北医大附属唐山工人医院耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1顾之燕.呼吸道炎症反应[J].中华耳鼻咽喉科杂志.2001,5:80.
2 Akbari O,Stock P,DeKruyff RH,et al.Role of regulatory Tcells in allergy and asthma[J].Curr Opin I mmunol,2003,15:627.
3 Gorelik L,Constant S,Flavell RA.Mechanism of transfor-ming growthfactor beta-inducedinhibition of Thelper type 1differentiation[J].J Exp Med,2002,195:1 499.
4 Chen CH,Seguin-Devaux C,Burke NA,et al.Transfor-ming growth factor beta blocks Tec kinase phosphorylation,Ca2+influx,and NFATc translocation causing inhibition of Tcell differentiation[J].J Exp Med,2003,197:1 689.
5 Fantini MC,Becker C,Monteleone G,et al.Cutting edge:TGF-beta induces a regulatory phenotype in CD4+CD25-Tcells through Foxp3 induction and down-regulation of Smad7[J].J I mmunol,2004,172:5 149.
6 Somers T,Goovaerts G,Schelfhout L,et al.Growth factorsin tympanic membrane perforations[J].AmJ Otol,1998,19:428.
7 Cooter MS,Eisma RJ,Burleson JA,et al.Transforming growthfactor-beta expression in otitis media with effusion[J].La-ryngoscope,1998,108:1 066.
8 Jono H,Xu H,Kai H,et al.Transforming growthfactor be-ta-Smad signaling pathway negatively regulates nontypeableHaemophilus influenzae-induced MUC5AC mucin transcrip-tion via mitogen-activated protein kinase(MAPK)phospha-tase-1-dependent inhibition of p38 MAPK[J].J Biol Chem,2003,278:27 811.