1 Proctor L,Perl man H,Lindsay J,et al.Acute vestibular pa-ralysis in herpes zoster oticus[J].Ann Otol Rhinol Laryngol,1979,88:303.

2 Tsuji K,Velasquez-Villasenor L,Rauch SD,et al.Temporal bonestudies of the human peripheral vestibular system.M啨ni埁re's dis-ease[J].Ann Otol Rhinol Laryngology,2000,181:S20.

3 Rauch SD.Vestibular histopathology of the human temporal bone.What can we learn[J]?Ann NY Acad Science,2001,942:25.

4 Wall CIII,Merfeld DM,Rauch SD,et al.Vestibular prosthe-ses:the engineering and biomedical issues[J].J Vestib Re-search,2002,12:95.

5 Corwin JT,Cotanche DA.Regeneration of sensory hair cellsafter acoustic trauma[J].Science,1988,240:1 772.

6 Ryals BM,Rubel EW.Hair cell regeneration after acoustictrauma in adult Coturnix quail[J].Science,1988,240:1 774.

7 Forge A,Li L,Corwin JT,et al.Ultrastructural evidence forhair cell regenerationin the mammalianinner ear[J].Science,1993,259:1 616.

8 Warchol ME,Lambert PR,Goldstein BJ,et al.Regenerativeproliferation in inner ear sensory epithelia from adult guineapigs and humans[J].Science,1993,259:1 619.

9 Tanyeri H,Lopez I,Honrubia V.Histological evidence for haircell regeneration after ototoxic cell destruction withlocal appli-cation of gentamicin in the chinchilla crista ampullaris[J].Hear Research,1995,89:194.

10 Li L,Forge A.Morphological evidence for supporting cell tohair cell conversion in the mammalian utricular macula[J].Int J Devel Neurosci,1997,15:433.

11 Rubel EW,Dew LA,Roberson DW.Mammalian vestibularhair cell regeneration[J].Science,1995,267:701.

12 Balak KJ,Corwin JT,Jones JE.Regenerated hair cells canoriginate fromsupporting cell progeny:evidence from photo-toxicity and laser ablation experi ments in the lateral line sys-tem[J].J Neuroscience,1990,10:2 502.

13 Girod DA,Duckert LG,Rubel EW.Possible precursors ofregenerated hair cells in the avian cochlea following accoustictrauma[J].Hear Research,1989,42:175.

14 Presson JC,Popper AN.Possible precursors to newhair cells,support cells,and Schwann cellsin the ear of a post-embry-onic fish[J].Hear Research,1990,46:9.

15 Baird RA,Torres MA,Schuff NR.Hair cell regenerationinthe bullfrog vestibular otolith organs following aminoglyco-side toxicity[J].Hear Research,1993,65:164.

16 Hashino E,Salvi R.Changing patterns of DNAreplicationinthe noise-damaged chick cochlea[J].J Cell Science,1993,105:23.

17 Tsue TT,Watling DL,Weisleder P,et al.Identification ofhair cell progenitors andintermitotic migration of their nucleiin the normal and regenerating avian inner ear[J].J Neuro-science,1994,14:140.

18 Raphael Y.Evidence for supporting cell mitosis in responseto acoustic trauma in the avian inner ear[J].J Neurocytolo-gy,1992,21:663.

19 Stone JS,Cotanche DA.Identification of the ti ming of S phaseand patterns of cell proliferation during hair cell regenerationin the chick cochlea[J].J Compr Neurology,1994,341:50.

20 Jones JE,Corwin JT.Regeneration of sensory cells after la-ser ablation in the lateral line system:hair cell lineage andmacrophage behavior revealed by ti me-lapse video microsco-py[J].J Neuroscience,1996,16:649.

21 Warchol ME,Corwin JR.Regenerative proliferationin organcultures of the avian cochlea:identification of the initial pro-genitors and determination of the latency of the proliferativeresponse[J].J Neuroscience,1996,16:5 466.

22 Presson JC,Lanford PJ,Popper AN.Hair cell precursorsare ultrastructurally indistinguishable from mature supportcells inthe ear of a post-embryonic fish[J].Hear Research,1996,100:10.

23 White PM,Doetzlhofer A,Lee YS,e tl.Mammalian cochlearsupporting cells can divide and trans-differentiate into haircells[J].Nature,2006,441:984.

24 Tanyeri H,Lopez I,Honrubia V.Histological evidence forhair cell regeneration after ototoxic cell destruction withlocalapplication of gentamicin in the chinchilla crista ampullaris[J].Hear Research,1995,89:194.

25 Kuntz AL,Oesterle EC.TGFalphainduces hair cell produc-tionin mature mammalian vestibular sensory epithelia in vivo[J].Assoc Res Otolaryngol Abstract,1996,19:790.

26 Zheng JL,Gao WQ.Analysis of rat vestibular hair cell devel-opment and regeneration using calretinin as an early marker[J].J Neuroscience,1997,17:8 270.

27 Katayama A,Corwin JT.Cochlear cytogenesis visualized throughpulse labeling of chick embryos in culture[J].J Compr Neu-rology,1993,333:28.

28 Steyger PS,Burton M,Hawkins JR,et al.Calbindin andparvalbumin are early markers of non-mitotically regenera-ting hair cellsin the bullfrog vestibular otolith organs[J].In-ternational J Develop Neuroscience,1997,15:417.

29 Robertson DW,Kreig CS,Rubel EW.Light microscopic evi-dence that direct transdifferentiation gives rise to new haircells in regenerating avian auditory epithelium[J].AuditortyNeuroscience,1996,2:195.

30 Adler HJ,Raphael Y.New hair cells arise fromsupportingcell conversion in acoustically damaged chick inner ear[J].Neuroscience Letters,1996,210:73.

31 Baird RA,Steyger PS,Schuff NR.Mitotic and nonmitotichair cell regenerationin the bullfrog vestibular otolith organs[J].Ann NY Acad Science,1996,781:59.

32 Adler HJ,Komeda M,Raphael Y.Further evidence for sup-porting cell conversion in the damaged avian basilar papilla[J].International J Develop Neuroscience,1997,15:375.

33 Stone JS,Leano SG,Baker LP,et al.Hair cell differentiationinchick cochlear epithelium after aminoglycoside toxicity:in vivoandin vitro observations[J].J Neuroscience,1996,16:6 157.

34 Whitehead MC,Morest DK.The growth of cochlear fibersand the formation of their synaptic endings in the avian innerear:a study withthe electron microscope[J].J Neuroscience,1985,14:277.

35 Forge A,Souter M,Denman Johnson K.Structural develop-ment of sensory cells in the ear[J].Sem Cell Devel Biology,1997,8:225.

36 Burgess BJ,Adams JC,Nadol JB.Morphologic evidence forinnervation of Deiters'and Hensen's cellsinthe guinea pig[J].Hear Research,1997,108:74.

37 Oesterle EC,Cunningham DE,Rubel EW.Ultrastructure ofhyaline,border,and vacuole cells in chick inner ear[J].JCompr Neurol,1992,318:64.

38 Jones JE,Corwin JT.Replacement of lateral line sensory or-gans during tail regenerationin salamanders:identification ofprogenitor cells and analysis of leukocyte activity[J].J Neu-roscience,1993,13:1 022.

39 Zheng JL,Keller G,Gao WQ.I mmunocytochemical and mor-pholoocal evidence for intracellular self—rep.ir as an i mpor-tant contributor tomammalian hair cell recovery[J].J Neuro-science,1999,19:161.

40 Li HW,Liu H,Stafen H.Pluripotent stem cells from adultmouse inner earlJJ[J].Nature Medicine,2003,9:293.

41 Lopez I,Honrubia V,Lee SC,et al.Quantification of theprocess of hair cell loss and recovery in the chinchilla Cristaampullaris after gentamicin treat ment[J].Internat J DevNeuroscience,1997,15:447.

42 Zine A,Aubert A,Qiu J,et al.Hes1 and Hes5 activities arerequired for the normal development of the hair cells in themammalianinner ear[J].J Neuroscience,2001,21:4 712.

43 Shailam R,Lanford PJ,Dolinsky CM,et al.Expression ofproneural and neurogenic genes in the embryonic mammalianvestibular system[J].J Neurocytology,1999,28:809.

44 Bermingham NA,Hassan BA,Price SD,et al.Math1:anessential gene for the generation of inner ear hair cells[J].Science,1999,284:1 837.

45 Zheng JL,Gao WQ.Overexpression of math1 induces robustproduction of extra hair cells in postnatal rat inner ears[J].Nat Neuroscience,2000,3:580.

46 Staecker H,Praetorius M,Baker K,et al.Vestibular hair cell re-generation and restoration of balance function induced by math1gene transfer[J].Otology&Neurotology,2007,28:223.

47 Kawamoto K,Ishi moto S,Minoda R,et al.Math1 genetransfer generates new cochlear hair cells in mature guineapigs in vivo[J].J Neurosci,2003,23:4 395.

48 Lambert PR.Inner ear hair cell regenerationin a mammal:identi-fication of a triggeringfactor[J].Laryngoscope,1994,104:701.

49 Shou J,Zheng JL,Gao WQ.Robust generation of new haircellsinthe mature mammalianinner ear by adenoviral expres-sion of hath1[J].Mol Cell Neuroscience,2003,23:169.

50 Praetorius M,Baker K,Weich CM,et al.Hearing preservationafter inner ear gene therapy:the effect of vector and surgical ap-proach[J].ORLJ Otorhinolaryngol Relat Spec,2003,65:211.

51 Staecker H,Li D,O'Malley BW,et al.Gene expression inthe mammalian cochlea:a study of multiple vector systems[J].Acta Otolaryngol,2001,121:157.

52 Lee KH,Cotanche DA.Potential role of bFGF and retinoicacid in the regeneration of chicken cochlear hair cells[J].Hear Research,1996,94:1.

53 Oesterle EC,Tsue TT,Rubel EW.Induction of cell proliferationin avianinner ear sensory epithelia byinsulin-like growth factorI andinsulin[J].J Compr Neurology,1997,380:262.

54 Warchol ME.Macrophage activityin organ cultures of the a-vian cochlea:demonstration of a resident population and re-cruit ment to sites of hair cell lesions[J].J Neurobiology,1997,33:724.

55 Navaratnam DS,Su HS,Scott SP,et al.Proliferationinthe au-ditory receptor epithelium mediated by cyclic AMP-dependentsignaling pathway[J].Nature Medicine,1996,2:1 136.

56 Yamashita H,Oesterle EC.Induction of cell proliferation inmammalian inner-ear sensory epithelia by transforminggrowth factor alpha and epidermal growth factor[J].ProcNatl Acad Science USA,1995,92:3 152.

57 Saffer LD,Gu R,Corwin JT.An RT-PCRanalysis of mR-NAfor growthfactor receptorsin damaged and control senso-ry epithelia of rat utricles[J].Hear Research,1996,94:14.

58 Pirvola U,Cao Y,Oellig C,et al.The site of action of neuronalacidic fibroblast growth factor is the organ of Corti of the ratcochlea[J].Proc Natl Acad Science USA,1995,92:9 269.

59 Zheng JL,Helbig C,Gao W.Induction of cell proliferation byfi-broblast andinsulin-like growthfactorsin pure rat inner ear epi-thelial cell cultures[J].J Neuroscience,1997,17:216.

60 Cotanche DA.Regeneration of hair cell stereociliary bundlesin the chick cochlea following severe acoustic trauma[J].Hear Research,1987,30:181.

61 Corwin JT,Jones JE,Katayama A,et al.Hair cell regenera-tion:the identities of progenitor cells,potential triggers andinstructive cues[J].Ciba Found Symp,1991,160:103.