Na-K-2Cl联合转运子1在小鼠耳蜗侧壁组织中的表达及意义
Immunohistochemical Localization of Na-K-2Cl Co-transporter in Mouse Cochlear Lateral Wall and Its Significance in Hearing
吴振恭;褚汉启;黄孝文;崔永华;
1:华中科技大学同济医学院附属同济医院耳鼻咽喉科
2:华中科技大学同济医学院附属同济医院耳鼻咽喉科
3:华中科技大学同济医学院附属同济医院耳鼻咽喉科
4:华中科技大学同济医学院附属同济医院耳鼻咽喉科 武汉430030
1 Delpire E,LuJ,England R,et al.Deafness andimbalance associated withinactivation of the secretory Na-K-2Cl co-transporter[J].Nat Genet.1999,22:192.
2 熊浩,褚汉启,韩芳,等.C57BL/6J小鼠耳蜗血管纹Na-K-2Cl联合转运子-1的年龄相关性变化[J].听力学及言语疾病杂志,2006,14:125.
3 Crouch JJ,Sakaguchi N,Lytle C,et al.Immunohistochemical local-izationof the Na-K-Cl co-transporter(NKCC1)inthe gerbil inner ear[J].HistochemCytochem,1997,45:773.
4 Wangemann P.Comparison of ion transport mechanisms between ves-tibular dark cells and strial marginal cells[J].Hear Res,1995,90:149.
5 Vetter DE,MannJR,Wangemann P,et al.Inner ear defectsinduced by null mutation of the isk gene[J].Neuron,1996,17:1251.
6 Lec MP,Ravenel JD,Hu RJ,et al.Targeted disruption of the kcnq1gene causes deafness and gastric hyperplasia in mice[J].J Clin In-vest,2000,106:1447.
7 Weber PC,Cunningham CD,Schulte BA.Potassiumrecycling path-ways inthe human cochlea[J].Laryngoscope,2001,111:1156.
8 Flagella M,Clarke LL,Miller ML,et al.Mice lackingthe basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf[J].Biol Chem,1999,274:26946.
9 Wangemann P.K+cycling and the endocochlear potential[J].Hear Res,2002,165:1.