缝隙连接蛋白Connexin与内耳发育的关系
林岚;王纾宜;李华伟;
1:复旦大学附属眼耳鼻喉科医院病理科
2:复旦大学附属眼耳鼻喉科医院病理科
3:复旦大学附属眼耳鼻喉科医院耳鼻咽喉头颈外科 上海200031
4:上海200031
1Nicholson SM,Bruzzone R.Gapjunctions:gettingthe message through[J].Curr Biol,1997,7:340.
2Gerido DA,White TW.Connexin disorders of the ear,skin,and lens[J].BiochimBiophys Acta,2004,23,1662:159.
3Bruzzone R.Learning the language of cell-cell communication through connexin channels[J].Genome Biol,2001,2:4027.
4Kikuchi T,Kimura RS,Paul DL,et al.Gapjunctions in the rat co-chlea:immunohistochemical and ultrastructural analysis[J].Anat Em-bryol,1995,191:101.
5Souter M,Forge A.Intercellularjunctional maturationinthe stria vas-cularis:possible association with onset and rise of endocochlear poten-tial[J].Hear Res,1998,119:81.
6Steel KP.The benefits of recycling[J].Science,1999,285:1363.
7Kikuchi T,Kimura RS,Paul DL,et al.Gap junction systems in the mammalian cochlea[J].Brain Res Rev,2000,32:163.
8Zhang YP,Tang WX,Ahmad S,et al.Gapjunction-mediatedintercel-lular biochemical couplingin cochlear supportingcellsinrequiredfor nor-mal cochlear functions[J].Proc Natl Acad Sci USA,2005,102:15201.
9Zhao HB.Connexin26is responsible for anionic molecule permeability inthe cochlea for intercellular signaling and metabolic communications[J].Eur J Neurosci,2005,21:1859.
10Sun JJ,Ahmad S,Chen Sp,et al.Cochlear gapjunctions coassem-bled from Cx26and30showfaster intercellular Ca2+signaling than homomeric counterparts[J].AmJ Physiol Cell Physiol,2005,288:C613.
11Kammen-Jolly K,Ichiki H,Scholtz AW,et al.Connexin26in hu-manfetal development of the inner ear[J].Hearing Res,2001,160:15.
12Rabionet R,Gasparini P,Estivill X.Molecular genetics of hearing impairment due to mutations in gapjunction gene encoding beta con-nexin[J].Hum Mutat,2000,16:190.
13Ahmad S,Chen S,Sun J,et al.Connexins26and30are coassem-bled toformgapjunctionsinthe cochlea of mouse[J].BiochemBio-phys Res Commun,2003,307:362.
14Yang JJ,Liao PJ,Su CC,et al.Expression patterns of connexin29(GJE1)in mouse and rat cochlea[J].Biochem Biophys Res Com-mun,2005,338:723.
15Eiberger J,Kibschull M,Strenzke N,et al.Expression pattern and functional characterization of connexin29in transgenic mice[J].Glia,2006,53:601.
16Tang W,Zhang Y,Chang Q,et al.Connexin29is highly expressed in cochlear Schwanncells,anditisrequiredforthe normal development and function of the auditory nerve of mice[J].J Neurosci,2006,26:1991.
17Lautermann J,Ten Cate WJ,Altenhoff P,et al.Expression of the gap-junction connexins26and30inthe rat cochlea[J].Cell Tissue Res,1998,294:415.
18Forge A,Becker D,Casalotti S,et al.Connexins and gapjunctions inthe inner ear[J].Audiol Neurootol,2002,111:190.
19Nickle R,Becker D,Forge A.Molecular and functional characte-rization of gapjunctions inthe avianinner ear[J].Journal of Neuro-science,2006,26:6190.
20Xia AP,Ikeda K,Katori Y,et al.Expression of connexin31inthe developing mouse cochlea[J].Neuroreport,2000,11:2449.
21Lopez-Bigas,Olive M,Rabionet R,et al.Connexin31(GJB3)is expressedinthe peripheral and auditory nerves and causes neuropathy and hearingimpairment[J].Hum Mol Genet,2001,10:947.
22Lopez-Bigas N,Arbones ML,Estivill X,et al.Expression profiles of the connexin genes,GJB1and GJB3,inthe developing mouse co-chlea[J].Mech Dev,2002,119(Suppl1):S111.
23Liu XZ,Xia XJ,Adams J,et al.Mutations in GJA1(connexin43)are associated with non-syndromic autosomal recessive deafness[J].Hum Mol Genet,2001,10:2945.
24Suzuki T,Takamatsu T,Oyamada M.Expressionof gapjunction pro-tein connexin43inthe adult rat cochlea:comparison withconnexin26[J].J HistochemCytochem,2003,51:903.
25Cohen-Salmon M,Maxeiner S,Kruger O,et al.Expression of the connexin43and connexin45-encoding genes in the developing and mature mouse inner ear[J].Cell Tissue Res,2004,316:15.
26Cohen-Salmon M,Ott T,Michel V,et al.Targeted ablation of connexin26in the inner ear epithelial gap junction network causes hearingimpairment and cell death[J].Curr Biol,2002,12:1106.
27Kudo T,Kure S,Ikeda K,et al.Transgenic expression of a domi-nant-negative connexin26causes degeneration of the organ of Cortiand non-syndromic deafness[J].Hum Mol Genet,2003,12:995.
28Teubner B,Michel V,Pesch J,et al.Connexin30(GJB6)-defi-ciency causes severe hearingimpairment andlack of endocochlear po-tential[J].Hum Mol Genet,2003,12:13.
29PlumA,Winterhager E,Pesch J,et al.Connexin31-deficiencyin mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation[J].Dev Biol,2001,231:334.
30Takashima H,Nakagawa M,Umehara F,et al.Gapjunction protein beta1(GJB1)mutations and central nervous systemsymptoms in X-linked Charcot-Marie-Tooth disease[J].Acta Neurol Scand,2003,107:31.
31Lecanda F,Warlow PM,Sheikh S,et al.Connexin43deficiency causes delayed ossification,craniofacial abnormalities,and osteoblast dysfunction[J].Journal of Cell Biology,2000,151:931.