KCNQ1在小鼠耳蜗血管纹的表达及在听觉中的意义
Expression of KCNQ1 in Stria Vascularis of Mouse Cochlea and Effects of KCNQ1 on Auditory Function
褚汉启;熊浩;韩芳;吴振恭;周良强;黄孝文;崔永华;
1:华中科技大学同济医学院附属同济医院耳鼻咽喉科华中科技大学同济医学院耳鼻咽喉科学研究所
2:华中科技大学同济医学院附属同济医院耳鼻咽喉科华中科技大学同济医学院耳鼻咽喉科学研究所
3:华中科技大学同济医学院附属同济医院耳鼻咽喉科华中科技大学同济医学院耳鼻咽喉科学研究所
4:华中科技大学同济医学院附属同济医院耳鼻咽喉科华中科技大学同济医学院耳鼻咽喉科学研究所
摘要关键词基金项目(Foundation):作者参考文献1 Wangemann P.K+cycling andregulationinthe cochlea and vestibular labyrinth[J].Audiol Neurootol,2002,7:199.
2 Schroeder BC,Waldegger S,Fehr S,et al.Aconstituivery open potas-siumchannel formal by KCNQ1and KCNE3[J].Nature,2000,403:196.
3 Casimiro MC,Knollmann BC,Ebert SN,et al.Targeted disruption of the Kcnq1gene produces a mouse model of Jervell and Lange-Nielsen Syndrome[J].Proc Natl Acad Sci USA,2001,98:2526.
4 Weber PC,Cunningham CD,Schulte BA,et al.Potassiumrecyclingpathways inthe human cochlea[J].Laryngoscope,2001,111:1156.
5 Shen Z,Marcus DC.Divalent cations inhibit Isk/KvlqtT1channels in excised membrane patches of strial marginal cells[J].Hear Res,1998,123:157.
6 Marcus DC,Shipley AM.Potassiumsecretion by vestibular daerk cell epitheliumdemonstrated by vibrating probe[J].Biophys J,1994:1937.
7 Spicer SS,Schulte BA.Evidence for a medial K+recycling pathway frominner hair cells[J].Hear Res,1998,118:1.
8 Shen Z,Marcus DC.Divalent cations inhibit Isk/Kvlqt1channels in excised membrane patches of strial marginal cells[J].Hear Res,1998,123:157.
9 Rivas A,Francisn HW.Inner ear abnormalities in a Kcnq1(Kvlqt1)knockout mouse:a model of Jervell and Lange-Nielsensyndrome[J].Otol Neurotol,2005,26:415.
10 Friedmann I,Fraser GR,FroggattmP,et al.Pathology of the ear in the cardio-auditory syndorome of Jervell and Lange-Nielsen(re-cessive deafness with electrocardiographic abnormalities)[J].J Lar-yngol Otol,1966,80:451.
11 Tyson J,Tranebjaerg L,Mcentagart M,et al.Mutationspectruminthe cardioauditory syndrome of Jervell and Lange-Nielsen[J].Hum Genet,2000,107:449.
12 刘文玲,胡大一,李萍,等.KCNQ1单一杂合突变导致Jervell-Lange-Nielsen综合征[J].中华心血管杂志,2005,33:41.
13 Crouch J,Sakaguchi N,Lytle C,et al.Immunohistochemical localiza-tion of the Na-K-Cl cotransporter(NKCC)in the gerbil inner ear[J].J HistochemCytochem,1997,45:773.