1Bodenner DL,Dedon PC,Katz JC,et al.Selective protection against cis-diamminedichloroplatinum(II)induced toxicity in kidney,gut,and bone marrow by diethyldithiocarbamate[J].Cancer Res,1986,46:2751.

2Chary KK,Higby DJ,Henderson ES,et al.Phase I study of high-dose cis-diamminedichloroplatinum(II)with forced diuresis[J].Cancer Treat Rep,1977,61:367.

3Cardinaal RM,Groot CMJ,Huizing EH,et al.Dose-dependent effect of8-day administration upon the morphology of the albino guinea pig cochlea[J].Hear Res,2000,144:135.

4廖英俊,汤浩.抗癌药顺铂耳毒性机制及防治方法的研究进展[J].生理科学进展,2003,34:266.

5Oh SH,Yu WS,Song BH,et al.Expression of heat shock protein72in rat cochlea with cisplatin-induced acute ototoxicity[J].Acta Otolaryngol,2000,120:146.

6Cardinaal RM,Groot CMJ,Huizing EH,et al.Cisplatin-induced ototoxicity:morphologyevidence of spontaneous outer hair cell recov-eryin albino guinea pigs[J].Hear Res,2000,144:147.

7Schaefer SD,Post JD,Close LG,et al.Ototoxicity of low-and moderate-dose cisplatin[J].Cancer,1985,56:1934.

8Cardinaal RM,Groot CMJ,Huizing EH,et al.Dose-dependent effect of8-day administration upon the morphology of the albino guinea pig cochlea[J].Hear Res,2000,144:135.

9WangJ,Faulconbridge RV,Fetoni A,et al.Local application of sodi-umthiosulfate prevents cisplatin-induced hearing loss in the guinea pig[J].Nearopharmacology,2003,45:380.

10De Groot JCMJ,Hamers FPT,Gispen WH,et al.Co-administra-tion of the neurotrophic ACTH(4-9)analogue,ORG2766,may reduce the cochleotoxic effects of cisplatin[J].Hear Res,1997,106:9.

11Meech RP,Campbell KCM,Hughes LP,et al.Asemiquantitative a-nalysis of the effects of cisplatinon the rat stria vascularis[J].Hear Res,1998,124:44.

12Strauss M,Towfighi J,Lipton A,et al.Cisplatinum ototoxicity:clinical experience and temporal bone histopathology[J].Laryngo-scope,1983,93:1554.

13EstremSA,Babin RW,Ryu JH,et al.Cis-diamminedichloroplati-num(II)ototoxicity in the guinea pig[J].Otolaryngol Head Neck Surg,1981,89:638.

14Sergi B,Ferraresi A,Troiani D,et al.Cisplatin ototoxicity in the guinea pig:vestibular andcochlear damage[J].Hear Res,2003,182:56.

16Schweitzer VG.Cisplatin-induced ototoxicity:the effect of pigmen-tation andinhibitory agents[J].Laryngoscope,1993,103(supple-ment):59.

17韩军,倪道凤,李奉蓉,等.应用畸变产物耳声发射和扩展高频测听对顺铂耳毒性的临床研究[J].中国耳鼻咽喉颅底外科杂志,2003,9:97.

18Stengs CHM,Klis SFL,Huizing EH,et al.Cisplatin ototoxicity:an electrophysiological dose-effect studyinalbino guinea pig[J].Hear Res,1998,124:99.

19Tsukasaki N,Whitworth CA,Rybak LP,et al.Acute changes in cochlear potentials due to cisplatin[J].Hear Res,2000,149:189.

20Ekborn A,Laurell G,Andersson A,et al.Cisplatin-induced hear-ingloss:influence of the mode of drug administration in the guinea pig[J].Hear Res,2000,140:38.

21Sie KCY,Norton SJ.Changesin otoacoustic emissions and auditory brain stemresponse after cisplatinumexposure in gerbils[J].Oto-laryngol Head Neck Surg,1997,116:585.

22Hatzopoulos S,Stefano MDI,Campbell KCM,et al.Cisplatin oto-toxicityinthe Sprague-Dawley rat evaluated by distortion product otoacoustic emissions[J].Audiology,2001,40:253.

23Hatzopoulos S,Petruccelli J,Laurell G,et al.Ototoxic effects of cis-platinin a Sprague-Dawley rat ani mal model as revealed by ABR and transiently evoked otoacoustic emission measurements[J].Hear Res,2002,170:70.

24Stephen J,O'Leary SFL,Klis SFL,et al.Perilymphatic application of cisplatin over several daysinalbino guineapigs:dose-dependency of electrophysiological and morphological effects[J].Hear Res,2001,154:135.

25Aguilar-Markulis NV,Beckley S,Priore R,et al.Auditorytoxicity effects of long-termcis-diamminedichloroplatinum(II)in man[J].Cancer Treat Rep,1979,63:1527.

26Stengs CHM,Klis SFL,Huizing EHH,et al.Cisplatin-induced ototoxicity,electrophysiological evdence of spontaneous recovery in the albino guinea pig[J].Hear Res,1997,111:103.

27Sluyter S,Klis SFL,De Groot JCMJ,et al.Alterations in the stria vascularisin relation to cisplatin ototoxicity and recovery[J].Hear Res,2003,185:49.

28李兰,王重远,郭晓峰,等.吖碇橙荧光染色技术对顺铂致聋机制的研究[J].临床耳鼻咽喉科杂志,1995,9:341.

29Rybak LP,Somani S.Ototoxicity:Amelioration by protective agents[Ototoxicity:Basic Science and Clinical Applicationsa:Part3:Cis-platin][J].Annals of the New York Academy of Sciences,1999,884:143.

30曹恒明,钱雪冶,迟放鲁,等.顺铂对耳蜗单离听觉细胞诱导型一氧化氮合酶表达的影响[J].听力学及言语疾病杂志,2001,9:27.

31Teranishi M,Nakashi ma T,Wakabayashi T.Effecs of tocopherol on cisplatin-induced ototoxicityin guinea pigs[J].Hear Res,2001,151:61.

32Alam SA,Ikeda K,Oshi ma T,et al.Cisplatin-induced apoptotic cell deathin Mongolian gerbil cochear[J].Hear Res,2000,141:28.

33许辉杰,黄魏宁.顺铂作用下沙鼠耳蜗螺旋神经元和Corti器细胞的凋亡[J].中华耳鼻咽喉科杂志,2003,38:98.

34Rybak LP,Whitworth C,Somani S.Application of antioxidants and other agents to prevent cisplatin[J].Ototoxicity,1999,109:1740.

35Lauretis AD,Capua BD,Barbieri ZZMT,et al.ABR evaluation of ototoxicityin cancer patients receiving cisplatin or carboplatin[J].Scand Audiol,1999,28:139.

36Ress BD,Sridhar KS,Balkany TJ,et al.Effects of cisplatinumchem-otherapy on otoacoustic emissions:the development of an objective screening protocol[J].Otolaryngology Head and Neck Surg,1999,121:693.

37Starvroulaki P,Apostolopoulos N,Segas J,et al.Evoked otoacoustic emission-an approach for monitoring cisplatin induced ototoxicity inchildren[J].International J of Pediatric Otolaryngol,2001,59:47.

38Sockalingam R,Freeman S,Cherny L,et al.Effect of high-dose cisplatin on auditory brainstemresponses and otoacoustic emissions inlaboratory ani mals[J].The American Journal of Otology,2000,21:521.