听神经病患者失匹配负波特征与言语识别率的关系

The Characteristic of Mismatch Negativity and the Relationship Between Mismatch Negativity and Speech Perception in Patients with Auditory Neuropathy

郭明丽;周娜;兰兰;陈之慧;于黎明;王秋菊;杨伟炎;

1:解放军总医院耳鼻咽喉-头颈外科

2:解放军总医院耳鼻咽喉-头颈外科

3:解放军总医院耳鼻咽喉-头颈外科

4:解放军总医院耳鼻咽喉-头颈外科

摘要
目的观察听神经病(auditory neuropathy,AN)患者失匹配负波(mismatch negativity,MMN)的基本特征及其与最大言语识别率(phonetic balanced maximum,PBmax)的关系。方法用IHS3099(Version3.82)型诱发电位仪对14例(19耳)AN患者和24例(24耳)听力正常者行MMN测试,用GSI-61双通道诊断型听力计和SONY Tc-Fx25盒式双声道立体声录音机及自行录制的单音节音素平衡词表磁带分别测试14例(19耳)AN患者和19例(19耳)听力正常者的PBmax,比较两组MMN潜伏期和振幅差异有无显著性意义,并分析MMN潜伏期和振幅与PBmax的相关性。结果与对照组相比,AN组MMN(强度差异和频率差异)潜伏期显著延长(P<0.01),AN组强度差异MMN振幅与对照组相比有显著性差异(P=0.019),两组频率差异MMN振幅无显著性差异(P=0.128);AN组频率差异和强度差异MMN潜伏期与PBmax呈部分负相关(r=-0.647,P<0.01;r=-0.708,P<0.01),对照组强度差异MMN潜伏期与PBmax也呈部分负相关(r=-0.643,P<0.05),但对照组频率差异MMN潜伏期与PBmax无相关性(r=-0.027,P=0.913)。结论MMN潜伏期相对稳定,振幅变异较大。AN组MMN潜伏期明显比对照组延长,在群体水平与PBmax呈部分负相关。MMN潜伏期在预估AN患者的言语识别能力方面有一定的意义。
关键词
听神经病;失匹配负波;最大言语识别率
基金项目(Foundation):
国家自然科学基金面上项目(30370782及30470956);; 国家“863”面上项目(2004AA221080);; 北京市重大科技项目(H020220020610)联合资助
作者
郭明丽;周娜;兰兰;陈之慧;于黎明;王秋菊;杨伟炎;
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