胶质细胞来源的神经营养因子对螺旋神经节神经元耳毒性损伤的保护作用
Protective Role of Glial Cell Line-Derived Neurotrophic Factor Following Ototoxic
朱雅颖;戴春富;余洪猛;王正敏;
1:复旦大学附属眼耳鼻喉科医院耳鼻咽喉科
2:复旦大学附属眼耳鼻喉科医院耳鼻咽喉科
3:复旦大学附属眼耳鼻喉科医院耳鼻咽喉科
4:复旦大学附属眼耳鼻喉科医院耳鼻咽喉科 上海200031
摘要关键词基金项目(Foundation):作者参考文献1 Lin LF,Doherty DH,Lile JD,et al.GDNF:a glial cell line-de-rived neurotrophic factor for midbrain dopaminergic neurons[J].Sci-ence,1993,260:1 130.
2 Ylikoski J,Pirvola U,Virkkala J,et al.Guinea pig auditory neuronsare protected by glial cell line-derived growth factor from degenerationafter noise trauma[J].Hear Res,1998,124:17.
3 St ve T,Nam YJ,Gong TW L,et al.Glial cell line-derived neu-rotrophic factor(GDNF)and its receptor complex are expressed in theauditory nerve of the mature rat cochlea[J].Hear Res,2001,155:143.
4 Nam YJ,St ve T,Hartman SS,et al.Upregulation of glial cell line-derived neurotrophic factor(GDNF)in the rat cochlea following noise[J].Hear Res,2000,146:1.
5 Yagi M,Magal E,Sheng Z,et al.Hair cells are protected fromaminoglycoside ototoxicity by adenoviral-mediated overexpression ofGDNF[J].Hum Gene Ther,1999,10:813.
6 Kawamoto K,Yagi M,St ve T,et al.Hearing and hair cells are pro-tected by adenoviral gene therapy with TGF-1 and GDNF[J].Molec-ular Ther,2003,4:484.
7 Leake PA,Hradek GT,Snyder RL.Chronic electrical stimulation by acochlear implant promotes survival of spiral ganglion neurons afterneonatal deafness[J].J Comp Neurol,1999,412:543.
8 Araki S,Atsushi K,Seldon HL,et al.Effects of chronic electricalstimulation on spiral ganglion neuron survival and size in deafened kit-tens[J].Laryngoscope,1998,108:687.
9 St ve T,Yagi M,Raphael Y.Transduction of the contralateral ear af-ter adenovirus-mediated cochlear gene transfer[J].Gene Ther,2000,7:377.
10 Kanzaki S,St ve T,Kawamoto K,et al.Glial cell line-derivedneurotrophic factor and chronic electrical stimulation prevent VIII cra-nial nerve degeneration following denervation[J].J Comp Neurol,2002,454:350.