热休克蛋白27在耳蜗基底膜上的表达及其意义
Expression of Heat Shock Protein 27 in the Basilar Membrane of Rat Cochlea
梅玲;黄治物;凡启军;肖伯奎;
1:武汉大学人民医院耳鼻咽喉-头颈外科
2:武汉大学人民医院耳鼻咽喉-头颈外科
3:武汉大学人民医院耳鼻咽喉-头颈外科
4:武汉大学人民医院耳鼻咽喉-头颈外科 武汉430060
1 凡启军,黄治物,梅玲,等.水杨酸钠作用后大鼠耳蜗、热休克蛋白27表达的研究[J].听力学及言语疾病杂志,2005,13:47.
2 Leonova EV,Fairfield DA,Lomax MI,et al.Constitutive expression of Hsp27inthe rat cochlea[J].Hea Res,2002,163:61.
3 Concannon CG,Gorman AM,Samali A.Onthe role of HSP27in re-gulating apoptosis[J].Apoptosis,2003,8:61.
4 Pack AK,Slepecky NB.Cytoskeletal and calcium-binding proteins inthe mammalian organ of corti:cell type-specific proteins displaying longitudinal and radial gradients[J].Hea Res,1995,91:119.
5 Fridberger A,Boutet de Monvel J,Ulfendahl M.Internal shearing withinthe hearing organ evoked by basilar membrane motion[J].The Journal of Neuros Sience,2002,22:9850.
6 Olson ES,Mountain DC.Mappingthe cochlear partition,stiffness to its cellulararchitecture[J].J Acoust Soc Am,1994,95:395.
7 Saha S,Slepecky NB.Age-related changes in microtubules in theguinea pig organ of Corti.Tubulin isoformshifts with increasing age suggest changesin micromechanical properties of the sensory epithelium[J].Cell Tissue Res,2000,300:29.
8 Brass D,Kemp DT.Analyses of mssbauer mechanica measure ment-sidicate that the cochlea is mechanically active[J].J Acoust Soc Am,1993,93:1502.
9 Sha SH,Taylor R,Forge A,et al.Differential vulnerability of basal and apical hair cells is based onintrinsic susceptibilitytofree radicals[J].Hea Res,2001,155:1.
10 Meyer zum Gottesberge AM,Felix H,Reuter A,et al.Ultrastructural and physiological defectsinthe cochlea of the Mpv17wouse strain.A comprison between yong and old adult animals[J].Hear Res,2001,156:69.
11 Preville X,Salvemini F,Giraud S,et al.Mammalian small stress pro-teins protectagainst oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activityand by maintainingop-timal cellular detoxifying machinery[J].Exp Cell Res,1999,247:61.
12 Hart FU,Hayer-Hart M.Molecular chaperones in the cytosol:from nascent chaintofolder protein[J].Science,2002,295:1852.
13 Hawkins JE.Comparative otopathology:aging,noise,and ototoxic drugs[J].Adv.Otorhinolaryngol,1973,20:125.