N型乙酰胆碱受体α10亚基在大鼠内耳耳蜗及前庭中的表达
Expression of α10 Acetylcholine Receptor Subunit mRNA in the Rat Cochlea and Vestibular
姚琦;孔维佳;程华茂;吴婷婷;夏交;朱云;
1:华中科技大学同济医学院附属协和医院耳鼻咽喉科
2:华中科技大学同济医学院附属协和医院耳鼻咽喉科
3:华中科技大学同济医学院附属协和医院耳鼻咽喉科
4:华中科技大学同济医学院附属协和医院耳鼻咽喉科
1 Anderson A,Troyanovskaya M,Wackym P.Differential expression ofα2~7,α9,andβ2~4nicotinic acetylcholine receptor subunit mRNA inthe vestibular end-organs and Scarpa’s ganglia of the rat[J].Brain Res,1997,778:409.
2 Elgoyhen AB,Johnson DS,Boulter J,et al.α9:an acetylcholine re-ceptor with novel pharmacological properties expressed in rat cochlear hair cells[J].Cell,1994,79:705.
3 Gerzanich V,Anand R,LindstromJ.Homomers ofα8andα7subunits of nicotinic receptors exhibit similar channel but contrastingbindingsite prop-erties[J].Mol Pharmacol,1994,45:212.
4 Hiel H,Elgoyen AB,Drescher DG,et al.Expression of nicotinic acetyl-choline receptor mRNAin the adult rat peripheral vestibular system[J].Brain Res,1996,738:347.
5 Elgoyhen A,Vetter D,Katz E,et al.Alpha10:Adeterminant of nico-tinic cholinergic receptor functionin mammalian vestibular and cochlear mechanosensory hair cells[J].Proc Natl Acad Sci,2001,98:3501.
6 Puel JL.Chemical synaptic transmissioninthe cochlea[J].Prog Neuro-biol,1995,47:449.
7 Oliver D,Klocker N,Schuck J,et al.Gating of Ca2+-ctivated K+-hannels controls fast inhibitory synaptic transmission t auditory outer hair cells[J].Neuron,2002,26:595.
8 Lustig LR,Hiel H,Fuchs PA.Vestibular hair cells of the chickexpressthe nicotinic acetylcholine receptor subunitα9[J].J Vestib Res,1999,9:359.
9 Morley BJ,Simmons DD.Developmental mRNAexpression of the al-pha10nicotinic acetylcholine receptor subunit in the rat cochlea[J].Brain Res Dev Brain Res,2002,139:87.
10 Chang KT,Berg DK.Nicotinic acetylcholine receptors containing al-pha7subunits are required for reliable synaptic transmission in situ[J].J Neurosci,1999,19:3701.
11 Dallos P,He DZ,Lin X,et al.Acetylcholine,outer hair cell electro-motility,andthe cochlear amplifier[J].J Neurosci,1997,17:2212.
12 Highstein SM.The central nervous systemefferent control of the organs of balance and equilibrium[J].Neurosci Res,1991,12:13.
13 Maroni P,Lysakowski A.Alpha-9nicotinic acetylcholine receptor subunit immunoreactivityinthe rodent inner ear[J].Assoc Res Oto-laryngol,1998,21:258.