脑活素拮抗豚鼠庆大霉素耳毒性机理的研究
Mechanism of Ceredrolysin Against Ototoxicity of Gentamycin in Guinea Pig
张帆;李再香;曹永茂;叶菁;熊杰;张琼;林凌;
1:武汉市中心医院耳鼻咽喉科
2:武汉市中心医院耳鼻咽喉科
3:武汉大学人民医院耳鼻咽喉-头颈外科
4:武汉市中心医院耳鼻咽喉科





1 钟玉旭,李复兰,邹立家,等.动物、脑水解物研究概述[J].中国生化药物杂志,1996,17:177.
2 刘维俊.几种脑组织注射液药理作用的比较研究[J].中国生化药物杂志,2000,21:223.
3 王正旋.脑活素在脑血管病康复期的临床后效观察[J].实用医技杂志,1994,4:933.
4 朱炯,孙磊.脑蛋白水解物注射液质量考核结果[J].中国药事,1997,11:258.
5 张帆,欧阳静萍.脑活素对豚鼠庆大霉素耳毒性保护作用的研究[J].医学新知杂志,2002,12:142.
6 董民声,董明敏,娄卫华.内耳疾病研究进展[M].郑州:河南医科大学出版社,1999.8~14.
7 Forge A,Schacht J.Aminoglycoside antibiotics[J].Audiology&Neuro-Otology,2000,5:3.
8 Gschanes A,Windisch M.The influnce of Cerebrolysin and E021on spatial navigation of24-month-oldrats[J].J Neural Transm,1998,53(suppl):313.
9 Staecher H,Gabaizadeh R,Federoff H,et al.Brain-derived neu-ritrophic factor gene prevents spiral ganglion degeneration after hair cell loss[J].Otolaryngol Head Neck Surg,1998,119:7.
10 Gonzalez ME,Francis L,Gastellane O.Antioxidant systemic effect of short-termcerebrolysin administration[J].J Neural Transm,1998,53(suppl):333.
11 蔡英姬,金哲珠,金河奎.猪胎脑活素注射液的研制[J].中国生化药物杂志,2000,21:12.
12 Smith MA,Makino S,Kvetnansky R,et al.Stress and glueocorticoids affectthe expression of brain-derived neurotrophic factor and neu-rotrophin-3mRNAs inthe hippocampus[J].J Neurosci,1995,15:1777.
13 Clarke PG,Posada A,Primi MP,et al.Neuron death in the central nervous systemduring development[J].Biomed Pharmacother,1998,52:356.
14 Alderson RF,Alterman AL,Barade YA,et al.Brain-derived neu-rotrophic factor increases survival and differentiated function of rat septal cholinergic neurons in cluture[J].Neuron,1990,5:297.
15 Zheng JT,Stewart RR,Gan WQ.Neurotrophin-4/5enhances sur-vival of culture spiral ganglion neurons and protects themfromcis-platin neurotoxicity[J].J Neurosci,1995,15:5079.
16 Avlla MS,Varela-Nieto I,Romero G,et al.Brain-derived neu-rotrophic factor and neurotrophin-3support the survival and neurito-genesis response of developing cochleoestibular ganglion neurons[J].Dev Biol,1993,159:266.
17 孙建军,刘钅延,汪家政,等.脑源性神经营养因子对培养听神经元生物学作用的观察[J].耳鼻咽喉—头颈外科杂志,1996,3:372.
18 孙建军,汪吉宝,李桂榕.生长因子对离子听神经元存活与轴突再生的影响[J].中华耳鼻咽喉科杂志,1996,31:274.
19 翟所强,郭维,胡吟燕.脑源性神经营养因子对螺旋神经节的保护作用[J].中华耳鼻咽喉科杂志,2002,37:109.