1Carnicero E,Zelarayan LC,Rutliger L,et al.Differential roles of fi-broblast growthfactor-2during development and maintenance of audi-tory sensory epithelia[J].J Neurosci Res,2004,77:787.

2Wright TJ,Hatch EP,Karabagli H,et al.Expression of mouse fibro-blast growth factor and fibroblast growth factor receptor genes during earlyinner ear development[J].Dev Dyn,2003,228:267.

3Cao X,Chen D.The BMP signaling and in vivo bone formation[J].Gene,2005,29,357:1.

4OkanoJ,Takigawa T,Seki K,et al.Transforminggrowthfactor beta2promotestheformation of the mouse cochleovestibular ganglionin organ culture[J].Int J Dev Biol,2005,49:23.

5Morsli H,Choo D,Ryan A,et al.Development of the mouse inner ear and originof its sensoryorgans[J].The Journal of Neuroscience,1998,18:3327.

6Mowbray C,Hammerschmidt M,Whitfield TT.Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line[J].Mech Dev,2001,108:179.

7Gerlach-Bank LM,Ellis AD,Noonen B,et al.Cloning and expres-sion analysis of the chick DANgene,an antagonist of the BMPfamily of growthfactors[J].Dev Dyn,2002,224:109.

8Thompson DL,Gerlach-Bank LM,Barald KF,et al.Retinoic acid repression of bone morphogenetic protein4in inner ear development[J].Mol Cell Biol,2003,23:2277.

9Levi G,Mantero S,Barbieri O,et al.Msx1and Dlx5act independently in development of craniofacial skeleton,but converge onthe regulation of Bmp signalingin palate formation[J].Mech Dev,2006,123:3.

10Ladher RK,Anakwe KU,Gurney AL,et al.Identification of syner-gistic signals initiating inner ear development[J].Science,2000,290:1965.

11Chang W,Nunes FD,de Jesus-Escobar JM,et al.Ectopic noggin blocks sensory and nonsensory organ morphogenesisinthe chickenin-ner ear[J].Dev Biol,1999,216:369.

12Pirvola U,Spencer-Dene B,Xing-Qun L,et al.FGF/FGF-2(II-Ib)signalingis essential forinner ear morphogenesis[J].J Neurosci,2000,20:6125.

13Riccomagno MM,Martinu L,Mulheisen M,et al.Specification of the mammalian cochlea is dependent on sonic hedgehog[J].Genes Dev,2002,16:2365.

14Burton Q,Cole LK,Mulheisen M,et al.The role of Pax2in mouse inner ear development[J].Dev Biol,2004,272:161.

15Ozaki H,Nakamura K,Funahashi J,et al.Six1controls patterning of the mouse otic vesicle[J].Development,2004,131:551.

16Xu PX,Adams J,Peters H,et al.Eya1-deficient mice lack ears and kidneys and showabnormal apoptosis of organ pripordia[J].Nat Gen-et,1999,23:113.

17Merlo GR,Paleari L,Mantero S,et al.The Dlx5homebox gene is es-sential for vestibular morphogenesis in the mouse embryo through a BMP-mediated pathway[J],Dev Bilo,2002,248:157.

18Wang W,Chan EK,Baron S,et al.Hmx2homeobox gene control of murine vestibular morphogenesis[J].Development,2001,128:5017.

19Karis A,Pata I,van Doorninck JH,et al.Transcriptionfactor GATA-3alters pathway selection of olivochochlear neurons and affects morphogenesis of the ear[J].J Comp Neurol,2001,429:615.

20Romand R,Niederreither K,Abu-Abed S,et al.Complementary expression patterns of retinoid acid-synthesizing and-metabolizing enzymes in pre-natal mouseinner ear structures[J].Gene Expr Pat-terns,2004,4:123.

21Morsli H,Tuorto F,Choo D,et al.Otx1and Otx2activities are requiredforthe normal development of the mouseinner ear[J].Devel-opment,1999,126:2235.

22Camarero G,Villar MA,Contreras J,et al.Cochlear abnormalities ininsulin-like growth factor-1mouse mutants[J].Hear Res,2002,170:2.

23Moraes F,Novoa A,Jerome-Majewska LA,et al.Tbx1is required for proper neural crest migrationandtostabilize spatial patterns during middle andinner ear development[J].Mech Dev,2005,122:199.

24Ma Q,Anderson DJ,Fritzsch B.Neurogenin1null mutant ears de-velopfewer,morphologically normal hair cellsin smaller sensory epi-thelia devoid of innervation[J].J Assoc Res Otolaryngol,2000,1:129.

25Fritzsch B,Tessarollo L,Coppola E,et al.Neurotrophins in the ear:their roles in sensory neuron survival and fiber guidance[J].Prog Brain Res,2004,146:265.

26Kim WY,Fritzsch B,Serls A,et al.NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during develop-ment[J].Development,2001,128:417.

27Salminen M,Meyer BI,Bober E,et al.Netrin1is required for semicircular canal formation in the mouse inner ear[J].Develop-ment,2000,127:13.

28Kelley MW.Cell adhesion molecules during inner ear and hair cell development,including notchanditsligands[J].Curr Top Dev Biol,2003,57:321.

29BerminghamNA,Hassan BA,Price SD,et al.Math1:an essential genefor the generation of inner ear hair cells[J].Science,1999,284:1837.

30Montcouquiol M,Rachel RA,Lanford PJ,et al.Identification ofVangl2and Scrb1as planar polarity genes in mammals[J].Nature,2003,423:173.

31Curtin JA,Quint E,Tsipouri V,et al.Mutation of Celsr1disrupts planar polarity of inner ear hair cells and causes severe neural tube defects inthe mouse[J].Curr Biol,2003,13:1129.

32Dabdoub A,Donohue MJ,Brennan A,et al.Wnt signaling mediates reorientation of outer hair cell stereociliary bundles inthe mammalian cochlea[J].Development,2003,130:2375.

33Zine A,Aubert A,Qiu J,et al.Hes1and Hes5activities are requiredforthe normal development of hair cellsinthe mammalianin-ner ear[J].J Neurosci,2001,21:4712.

34Chen P,Segil N.p27(Kip1)links cell proliferationto morphogenesis inthe developingorgan of Corti[J].Development,1999,126:1581.

35Mueller KL,Jacques BE and Kelley MW.Fibroblast growth factor signalingregulates pillar cell development inthe organ of corti[J].J Neurosci,2002,22:9368.

36Lawoko-Kerali G,Rivolta MN,Holley M.Expression of the tran-scriptionfactors GATA3and Pax2during development of the mam-malianinner ear[J].J Comp Neurol,2002,442:378.

37Clough RL,Sud R,Davis-Silberman,et al.NBrn-3c(POU4F3)regulates BDNFand NT-3promoter activity[J].Biochem Biophys Res Commun,2004,324:372.

38Wallis D,Hamblen M,Zhou Y,et al.The zinc finger transcription factor growthfactor Gfi1,implicatedinlymphomagenesis,is required for inner ear hair cell differentiation and survival[J].Development,2003,130:221.

39Li S,Price SM,Cahill H,et al.Hearingloss caused by progressive degeneration of cochlear hair cell sin mice deficient for Barhl1ho-meobox gene[J].Development,2002,129:3523.

40Van De Water TR,Lallemend F,Eshraghi AA,et al.Caspases,the enemy within,andtheir role in oxidative stress-induced apoptosis of inner ear sensory cells[J].Otol Neurotol,2004,25:627.

41Self T,Sobe T,Copeland NG,et al.Role of myosin VI inthe differ-entiation of cochlear hair cells[J].Dev Biol,1999,214:331.

42Senften M,Schwander M,Kazmierczak P,et al.Physical andfunc-tional interaction between protocadherin15and myosin VIIain mecha-nosensory hair cells[J].J Neurosci,2006,26:2060.

43Zheng L.The deaf jerker mouse has a mutationinthe gene encoding the espin actin-bundling proteins of hair cells stereocilia and lacks espins[J].Cell,2000,102:377.

44Takebayashi S,Nakagawa T,Kojima K,et al.Expression of beta-cateninin developing auditory epithelia of mice[J].Acta Otolaryngol Suppl,2004,551:18.

45Kelley MW.Cell adhesion molecules duringinner ear and hair cell de-velopment,including notch and its ligands[J].Curr Top Dev Biol,2003,57:321.

46Pilipenko VV,Reece A,Choo DI,et al.Genomic organization and expression analysis of the murine Fam3c gene[J].Gene,2004,335:159.

47Ponnio T,Burton Q,Pereira FA.The nuclear Nor-1is essential for proliferation of the semicircular canals of the mouseinner ear[J].Mol Cell Biol,2002,22:935.

48Hadrys T,Braun T,Rinkwitz-Brandt S,et al.Nkx5-1controls semicircular canal formation in the mouse inner ear[J].Develop-ment,1998,125:33.

49Jukkola T,Sinjushina N,Partanen J.Drapc1expression during mouse embryonic development[J].Gene Expr Patterns,2004,4:755.

50Fritzsch B,Tessarollo L,Coppola E,et al.Neurotrophins in the ear:their roles in sensory neuron survival and fiber guidance[J].Prog Brain Res,2004,146:265.

51Cohen-Salmon M,Maxeiner S,Kruger O,et al.Expression of the connexin43-and connexin45-encoding genesinthe developing and mature mouse inner ear[J].Cell Tissue Res,2004,316:15.

52Hafidi A,Dulon D.Developmental expression of Ca(v)1.3(alpha1d)calciumchannels in the mouse inner ear[J].Brain Res Dev Brain Res,2004,150:167.

53Dechesne CJ,Thomasset M.Calbindin(CaBP28kDa)appearance and distribution during development of the mouse inner ear[J].Brain Res,1988,468:233.

54Nicolas M,Dememes D,Martin A,et al.KCNQ1/KCNE1potassium channelsin mammalian vestibular dark cells[J].Hear Res,2001,153:132.

55Mhatre AN,Stern RE,Li J,et al.Aquaporin4expression in the mammlianinner ear andits role in hearing[J].BiochemBiophys Res Commun,2002,297:987.

56Penheiter AR,Friedman RA,Croy CL,et al.Characterization of the deafwaddler mutant of the rat plasma membrane calcium-ATPase2[J].Hear Res,2001,162:19.

57Jin ZH,Kikuchi T,Tanaka K,et al.Expression of glutamate trans-porter GLASTin the developing mouse cochlea[J].Tohoku J Exp Med,2003,200:137.

58Xu Q,Wang Y,Dabdoub A,et al.Vascular development inthe ret-ina andinner ear:control by Norrin and Frizzled-4,a high-affini-tyligand-receptor pair[J].Cell,2004,116:883.