听神经病与前庭上、下神经损害的关系

The Relationship Between Auditory Neuropathy and Superior and Inferior Vestibular Nerve Impairment

王锦玲;石力;孙伟;谢娟;韩丽萍;高磊;

1:第四军医大学西京医院全军耳鼻咽喉专科中心

2:第四军医大学西京医院全军耳鼻咽喉专科中心

3:第四军医大学西京医院全军耳鼻咽喉专科中心

4:第四军医大学西京医院全军耳鼻咽喉专科中心

摘要
目的观察听神经病(auditory neuropathy,AN)患者伴发前庭上、下神经损害的特点,分析其与AN的关系。方法检测70例AN患者的眼震电图(electronystagmography,ENG)及前庭诱发肌源性电位(vestibular evoked myo-genic potential,VEMP),观察VEMP波形、潜伏期及振幅,并与对照组比较,分析前庭神经受损与AN患者听力损害程度、年龄及病程的关系。结果70例(139耳)AN患者中VEMP引出38耳(27.3%),未引出101耳(72.7%),ENG冷热试验半规管功能正常106耳(76.3%),异常33耳(23.7%),两种检测结果差异有显著统计学意义(P<0.01)。VEMP引出的38耳中,左、右耳的潜伏期均值P13为24.54±5.388及25.17±6.068ms,N23为31.38±5.766及32.02±6.058ms,对照组P13为17.04±1.781及17.49±2.291ms;N23为25.05±2.864及25.81±3.273ms,两组差异有显著统计学意义(P<0.01);左、右耳的振幅均值为60.16±34.732及43.83±31.288μV,对照组为147.16±50.026及135.66±54.737μV,两组差异有显著统计学意义(P<0.01)。AN患者VEMP是否引出与听力损害程度有相关性(P<0.05),与年龄及病程无相关性(P>0.05)。AN患者ENG的半规管功能是否正常与病程有相关性(P<0.05),与听力损害程度及年龄无相关性(P>0.05)。结论AN患者伴发前庭下神经损害的几率远大于前庭上神经,表现为VEMP波形未引出或潜伏期延长、振幅低;VEMP是否引出与听力损害程度有相关性,ENG的半规管功能异常与病程有相关性,提示AN患者听神经病变极易累及前庭下神经及其终器球囊;VEMP与ENG联合应用可对AN伴发前庭神经病变的范围作出较全面可靠的评估,应作为AN诊断常规检查项目之一。
关键词
听神经病;前庭诱发肌源性电位;眼震电图
基金项目(Foundation):
作者
王锦玲;石力;孙伟;谢娟;韩丽萍;高磊;
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