不同发育阶段豚鼠耳蜗外侧壁中mdr_1mRNA的表达及其意义
Expression and Significance of mdr_1mRNA in Guinea Pig Cochlea Lateral Wall at Different Developmental Stages
张学渊;周亚光
1:第三军医大学西南医院耳鼻咽喉科
2:成都军区昆明总医院耳鼻咽喉科 (重庆400038)
摘要关键词基金项目(Foundation):作者参考文献1 TakehisaS ,ZhangZJ,MasaharuT ,etal.Expressionofmultidrugre sistanceprotein1(MRP1)intheratcochleawithspecialreferencetotheblood-inneearbarrier[J].BrainRes,2001,895:253.
2 GaillardPJ,vanderSandtIC ,VoorwindenLH ,etal.Astrocytesin creasethefunctionalexpressionofP -glycoproteininaninvitromodeloftheblood-brainbarrier[J].PharmRes,2000,17:1198.
3 AbrahamEH ,SterlingKM ,KimRJ,etal.ErythrocytemembraneATPbindingcassette(ABC)proteins:MRP1andCFTRaswellasCD39(ect-apyrase)involvedinABCATPtransportandelevatedbloodplasmaATPofcysticfibrosis[J].BloodCellsMolDis,2001,27:165.
4 RaymondM ,GrosP ,WhitewagM ,etal.FunctionalcomplementationofYeastste6byamammalianmultidrugresis-tancemdr1 gene[J].Science,1992,256:232.
5 SchinkelAH ,RoelofsEM ,BorstP ,etal.CharacterizationofthehumanMDR3P -glycoproteinanditsrecognitionbyP -glycoprotein-specif icmonoclonalantibodies.CancerRes,1991,51:2628.
6 RoepePD .WhatisthepreciseroleofhumanMDR1proteininchemotherapeuticdrugresistance[J].CurrPharmDes,2000,6:241.
7 SchinkelAH ,SmitJJM ,vanTellingenO ,etal.Disruptionofthemousemdr1 aP -glycoproteingeneleadstoadeficiencyintheblood-brainbarrierandtoincreasedsensitivitytodrugs[J].Cell,1999,7:491.
8 ZhangZJ,SaitoT ,KimuraY ,etal.Disruptionofmdr1 ap-glycopro teingeneresultsindysfunctionofblood-innerearbarrierinmice[J].BrainRes,2000,852:116.
9 JuhnSK .Barriersystemsintheinnerear[J].ActaOtolarynogol,1988,458:79.
10 SakagamiM ,MatsunagaT ,HashimotoPH ,etal.Finestructureandpermeabilityofcapillariesinthestriavascularisandspiralligamentoftheinnerearoftheguineapig[J].CellTissueRes,1982,226:511.
11 SaitoT ,ZhangZJ,TsuzukiH ,etal.ExpressionofP -glycoproteinininnerearcapillaryendothelialcellsoftheguineapigwithspecialreferencetoblood-innerearbarrier[J].BrainRes,1997,767:388.
12 SaitoT ,ZhangZJ,TokurikiM ,etal.CyclosporinAinhibitstheex trusionpumpfunctionofP -glyco-proteinintheinnerearofmicetreatedwithvinblastineanddoxorubicin[J].BrainRes,2001,901:265.
13 HenleyCM ,RybakLP .Ototoxicityindevelopingmammals[J].BrainRes,1995,20:68.