1Hossain WA,Brumwell CL,Morest DK.Sequential interactions of fi-broblast growthfactor-2,brain-derived neurotrophic factor,neuro-trophin-3,andtheir receptors define critical periods in the develop-ment of cochlear ganglion cells[J].Exp Neurol,2002,175:138.

2Van De Water TR,Staecker H,Ernfors P,et al.Neurotrophic factors as pharmacological agents for the treatment of injured auditory neurons[J].Ciba Found Symp,1996,196:149.

3Staecker H,Liu W,Hartnick C,et al.NT-3combined with CNTF promotes survival of neuronsin modiolus-spiral ganglion explants[J].Neuroreport,1995,66:1533.

4余云开,华仲慰,李玉书.神经营养素家族[J].国外医学分子生物学分册,1995,17:127.

5Fritzsch B,Pirvola U,Ylikoski J.Making and breaking the innerva-tion of the ear:neurotrophic support during ear development and its clinical implications[J].Cell Tissue Res,1999,295:369.

6Fritzsch B,Farinas I,Reichardt LF.Lack of neurotrophin3causes losses of both classes of spiral ganglion neurons inthe cochlea in a re-gion-specific fashion[J].J Neurosci,1997,17:6213.

7ErnforsP,Van De Water TR,LoringJ,et al.Complementaryroles of BDNFand NT-3investibular and auditory development[J].Neuron,1995,14:1153.

8Staecker H,Galinovic-Schwartz V,Liu W,et al,The role of the neurotrophins in maturation and maintenance of postnatal auditory in-nervation[J].AmJ Otol,1996,17:486.

9Smith MA,Makino S,Kvetnansky R,et al.Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neuro-trophin-3mRNAin the hippocampus[J].J Neurosci,1995,15:1768.

10Staecker H,Kopke R,Malgrange B,et al.NT-3and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells[J].Neuroreport,1996,7:889.

11Shoji F,Miller AL,Mitchell A,et al.Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss[J].Hear Res,2000,146:134.

12杨卫平,胡博华,郭维,等.两种神经营养因子对噪声性毛细胞损伤协同防护作用的观察[J].中华耳鼻咽喉科杂志,2001,36:342.

13郭维,胡吟燕,周娜,等.NT-3重组腺病毒对耳蜗螺旋神经节的保护作用[J].听力学及言语疾病杂志,2002,10:247.

14Zheng JL,Gao WQ.Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures[J].Eur J Neurosci,1996,8:1897.

15Ernfors P,Duan ML,Elshamy WM,et al.Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3[J].Nat Med,1996,2:463.

16Zheng JL,Stewart RR,Gao WQ.Neurotrophin-4/5,brain-derived neurotrophic factor,and neurotrophin-3promote survival of cultured vestibular ganlion neurons and protect themagainst neurotoxicity of ototoxins[J].J Neurobiol,1995,28:330.

17Duan M,Agerman K,Ernfors P,et al.Complementaryroles of neu-rotrophin3and a N-methyl-D-aspartate antagonist inthe protec-tion of noise and aminoglycoside-induced ototoxicity[J].Proc Natl Acad Sci US A,2000,97:7597.

18Rapheal Y,Frisancho JC,Roessler B.Adenoviral-mediatedgenet-ransferinto guinea pig cochlear cell sinvivo[J].Neuro-science Let-ters,1996,207:137.

19Derby ML,Sena-Esteves M,Breakefield XO,et al.Gene transfer intothe mammalianinner ear using HSV-1and vaccinia virus vec-tors[J].Hear Res,1999,134:1.

20Chen X,Frisina RD,Bowers WJ,et al.HSVamplicon-mediatedneurotrophin-3expression protects murine spiral ganglion neurons fromcisplatin-induced damage[J].Mol Ther,2001,3:958.

21Bowers WJ,Chen X,Guo H,et al.Neurotrophin-3transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea[J].Mol Ther,2002,6:12.

22邓志宏,邱建华,王锦玲,等.NT3基因转染对小鼠耳蜗螺旋神经节细胞生长的影响[J].中华神经外科疾病研究杂志,2004,3:249.

23陈谦,吴燕,郭维维,等.BDNF基因对噪音引起的听神经元损伤的保护作用[J].解剖学报,2003,2:95.

24高下,王锦玲,杨安钢,等.NT-3基因工程细胞经脑脊液途径的耳蜗内生物学效应的初步证明[J].听力学及言语疾病杂志,2002,10:255.

25Gleich LL.Gene therapy for head and neck cancer[J].Laryngo-scope,2000,110:708.

26Crystal RG.Transfer of genes to human:early lessons and obstacles to success[J].Science,1995,270:404.