阳离子脂质体介导NT-3基因转染豚鼠耳蜗的实验研究
Cationic Liposome Medicated Transgene Expression in Guinea Pig Cochlea
邓志宏;王锦玲;邱建华;刘顺利;王成济;杨安钢
1:第四军医大学西京医院耳鼻咽喉科
2:第四军医大学西京医院耳鼻咽喉科
3:第四军医大学西京医院耳鼻咽喉科
4:第四军医大学西京医院耳鼻咽喉科
摘要关键词基金项目(Foundation):作者参考文献1 QunLX ,PirvolaU ,SaarmaM ,etal.Neurotrophicfactorsintheaudito ryperiphery[J].AnnNYAcadSci,1999,884:292.
2 HossainWA ,BrumwellCL ,MorestDK .Sequentialinteractionsoffibro blastgrowthfactor-2,brain-derivedneurotrophicfactor,neurotrophin-3,andtheirreceptorsdefinecriticalperiodsinthedevelopmentofcochlearganglioncells[J].ExpNeurol,2002,175:138
3 GaoWQ .Roleofneurotrophinsandlectinsinpreventionofototoxicity[J].AnnNYAcadSc,1999,884:312.
4 ShojiiF ,MillerAL ,MitchellA ,etal.Differentialprotectiveeffectsofneurotrophinsintheattenuationofnoise-inducedhaircellloss[J].HearRes,2000,146:134.
5 AletseeC ,BrorsD ,MlynskiR ,etal.Wortmannin,aspecificinhibitorofhosphatidylinositol-3-kinaseinfluencesneurotrophin-inducedspiralganglionneuritegrowth[J].Laryngorhinootologie,2002,81:189.
6 RuanRS ,LeoooongSK ,MarkI,etal.EffectsofBDNFandNT -3onhaircellsurvivalinguineapigcochleadamagedbykanamycintreat ment[J].Neurorepor,1999,10:2067.
7 邓志宏,王锦玲,邱建华,等.人神经营养因子NT -3-cDNA基因的克隆及其真核表达载体的构建[J].第四军医大学学报,2002,23:1757.
8 CamiceroE ,KnipperM ,YanJ,etal.Herpessimplexvirustype1-mediatedtransferofneurotrophin-3stimulatessurvivalofchickenau ditorysensoryneurons[J].NeurosciLett,2002,321:149.
9 DerbyML ,Sene-EstevesM ,BreakefieldXO ,etal.GenetransferintothemammalianinnerearusingHSV -1andvacciniavirusvectors[J].HearRes,1999,134:1.
10 StoverT ,YagiM ,RaphaelY .Cochleargenetransfer:roundwindowversuscochleostomyinoculation[J].HearRes,1999,136:124.
11 StoverT ,YagiM ,RaphaelY .Transductionofthecontralateralearaf teradenovirus-mediatedcochleargenetransfer[J].GeneTher,2000,7:377.
12 WareingM ,MhatreAN ,PettisR ,etal.Cationicliposomemediatedtransgeneexpressionintheguineapigcochlea[J].HearRes,1999,128:61.
13 ZhuN ,LiggittD ,LiuY ,etal.Systemicgeneexpressionafterintrave nousDNAdeliveryintoadultmice[J].Science,1993,261:209.
14 HsiaoM ,TseV ,CarmelJ,etal.Stabilizationofcationicliposome-plasmidDNAcomplexesbypolyaminesandpoly(ethyleneglycol)-phospholipidconjugatesforefficientinvivogenedelivery[J].FEBSLett,1997,400:233.
15 GillDR ,SouthernKW ,MoffordKA ,etal.Aplacebo-controlledstudyofliposome-mediatedgenetransfertothenasalepitheliumofpatientswithcysticfibrosis[J].GeneTher,1997,4:199.
16 HeimR ,CubittAB ,TsienRY .Improvedgreenfluorescence[J].Na ture,1995,373:663.
17 LalwaniAK ,HanJJ,WalshBJ,etal.Greenfluorescentproteinasareporterforgenetransferstudiesinthecochlea[J].HearRes,1997,114:139.