卡铂对离体培养成年灰鼠前庭毛细胞的损害

Carboplatin Induced Vestibular Hair Cell Lesion in the Adult Chi nchilla Organotypic Cultures

丁大连;蒋海燕;王家东;杨军;Richard J.Salvi

1:Center for Hearing and Deafness

2:State University of NewYork at Buffalo

3:Center for Hearing and Deafness

4:State University of NewYork at Buffalo

摘要
目的 观察并建立不同浓度卡铂损害成年灰鼠前庭终器的离体实验模型。方法 应用前庭终器分离取材技术、前庭器官离体培养技术和组织学检查技术 ,观察不同浓度卡铂对成年灰鼠前庭各终器的损害。结果 卡铂主要损害灰鼠前庭I型毛细胞 ,这种损害随着卡铂剂量的增加而加重。结论 卡铂选择性破坏离体培养的灰鼠前庭I型毛细胞
关键词
器官培养;卡铂;前庭毛细胞
基金项目(Foundation):
国家自然科学基金资助课题 (编号 3 0 10 0 2 0 6)
作者
丁大连;蒋海燕;王家东;杨军;Richard J.Salvi
参考文献

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