正常清醒豚鼠的畸变产物耳声发射特性

Characteristics of Distortion Product Otoacoustic Emissions in Normal Awaked Guinea Pigs

罗燕云;黄治物;吴展元;肖伯奎

1:武汉大学人民医院耳鼻咽喉-头颈外科

2:武汉大学人民医院耳鼻咽喉-头颈外科

3:武汉大学人民医院耳鼻咽喉-头颈外科

4:武汉大学人民医院耳鼻咽喉-头颈外科 武汉430060

摘要
目的 研究正常清醒豚鼠的畸变产物耳声发射(DPOAE)的特性。方法 采用CELESTA 503型耳声发射分析仪对26只正常清醒豚鼠(35耳)进行DP图及DP输入/输出曲线(DP-I/O)的测试,随机选择11只正常清醒豚鼠(20耳)进行DPOAE的重复测试,用SPSS10.0对数据进行统计分析。结果 在DP图中,当初始音强度L1/L2为 70/65 dB SPL时,正常清醒豚鼠的 DPOAE幅值随测试频率f0从0.75-8kHz的增加而逐渐升高(27.90±1.96-50.65±0.71)。在 DP-I/O中,当f0分别为4、6、8 kHz时,正常清醒豚鼠的DPOAE幅值随L1/L2从70/65以5dB-挡降至15/10 dB SPL而呈线性下降(P<0.01),在L1/L2为55/50或60/55 dB SPL处出现饱和或低谷,同一I/O曲线上L1/L2分别从70/65及55/50 dB SPL递减至阈值的I/O斜率(分别记为KT及KL)均接近于1,且KL大于KT(P<0.01)。重复测试的DPOAE幅值差异小(< 1dB SPL)且无统计学意义(P>0.05)。结论 正常清醒豚鼠DPOAE测试充分表现了其捡出率高、反应幅值大?
关键词
畸变产物耳声发射;豚鼠
基金项目(Foundation):
国家自然科学基金资助项目(项目编号:30000190)
作者
罗燕云;黄治物;吴展元;肖伯奎
参考文献

1 Probst R. Otoacoustic emissions: an overview[J]. Adv Otorhinolaryngol, 1990,44:1.

2 Norton SJ. Cochlear function and otoacoustic emissions[J]. Seminars in hearing, 1992,13:1.

3 梁勇,钟乃川.豚鼠畸变产物耳声发射正常值测试及其相互关 系[J].临床耳鼻咽喉科杂志,1998,12:124.

4 Whitehead ML, McCoy MJ, Lonsbury-Martin BL, et al. Dependence of distortion-product otoacoustic emissions on primary levels in normal and impaired earn: I. Effects of decreasing L2 below L1[J]. .J Acoust Soc Am, 1995,97:2346.

5 Whitehead ML, Lonsbury-Martin BL, Martin GK. Evidence for two discrete sources of 2f1-f2 distortion-product otoacoustic emission in rabbit: I. Differential dependence on stimulus parameters[J]. J A- coust Soc Am, 1992,91:13.

6 Whitehead ML, Lonsbury-Martin BL, Martin GK. Evidence for two discrete sources of 2f1-f2 distortion-product otoacoustic emission in rabbit: Ⅱ. Differential physiological vulnerability[J]. J Acoust Soc Am, 1992,92:2662.

7 Frolenkov GI, Belyantseva IA, Kurc M, et al. Cochlear outer hair cell electromotility can provide force for both low and high intensity distor- tion product otoacoustic emissions[J]. Hear Res, 1998,126:67.

8 廖华,吴展元,周涛,等.正常听力青年人诱发性耳声发射测 试[J].听力学及言语疾病杂志,1997,5:133.

9 Nelson DA, Kimberley BP. Distortion-product emissions and auditory sensitivity in human ears with normal heating and cochlear heating loss

[J]. I Speech Hear Res, 1992,35:1142.

10 Abdala C. Distortion product otoacoustic emission(2f1-f2) amplitudegrowth in human adults and neonates[J]. J Acoust Soc Am, 2000, 107:446.

11 Whitehead ML, Lonsbury-Martin BL, Martin GK. Relevance of an- imal models to the clinical application of otoacoustic emissions[J]. Seminars in hearing, 1992,13:81.

12 Avan P, Loth D, Menguy C, et al. Evoked otoacoustic emissions in guinea pig: Basic characteristics[J]. Hear Res, 1990,44:151.

13 Cacace AT, McClelland WA, Weiner J, et al. Individual differences and the reliability of 2f1-f2 distortion-product otoacoustic emissions:Effects of time-of-day, stimulus variables, and gender[J]. J Speech Hear Res, 1996, 39:1138.

14 Shehata-Dieler WE, Dieler R, Teichert K, et al. Intra-and in- tersubject variability of acoustically evoked otoacoustic emissions: Ⅱ. Distortion product otoacoustic emissions[J]. Laryngorhinootologie, 1999, 78:345.

15 Hoshino M, Ueda H, Nakata S. Long-term stability between click-evoked otoacoustic emissions and distortion product otoacoustic e- missions in guinea pig: A comparision[J]. ORL J Otorhinolaryngol Relat Spec, 1999,61:175.

16 Whitehead ML, Lonsbury-Martin BL, Martin GK. Slow variation of the amplitude of acoustic distortion at f2-ft in awake rabbits[J]. Hear Res, 1991,51:116.

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畸变产物耳声发射豚鼠

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罗燕云黄治物吴展元肖伯奎