1 Acheson A,Conover CC,Fand .JP,et al A BDNF autocrine loop in adult sensory neurons Pr vents cell death[J]. Nature,1995,374:450.

2 Ernfors P. Van de Water TR, Loring J, et al.Complementary roles of BDNF and NT-3 in vestibular and auditory development[J]. Nature, 1995,14:1153.

3 Maness LM, Kastin AJ, Weber IT, et al. The neurotrophin and their receptors structure, function, and neuropathology[J]. Neurosci Behav Rev, 1994, 18:143.

4 Bianchi LM, Cohan CS. Developmental regulation of a neurite-promoting factor influencing statoacoustic neurons[J]. Dev Brain Tee, 1991, 64:167.

5 Staecker H, Van de Water TR, Lefebvre PP, Ct 81. NGF, BDNF, and NT-3 play unique roles in the in viva development and patterning of the mammalian inner ear[J]. Dev Brain Res, 1996,92:49.

6 Pirvola U, Arumae U, Moshnyakov M, et a1. Coorinated exproession and function of neurotrophins and their receptors in the rat inner ear dining targent innervation[J]. Hear Res,1994,75:131.

7 Wheeler ME, Corwin 11'. Supporting cells in avian vestibular organs pro- liferate in serum-free culture[J]. Hear Res, 1994,73:46.

8 Schecterson LC, Bothwell M. Neurotrophin and neurotrophin receptor mRNA expresion in developing inner ear[J]. Hear Res, 1994,73:92.

9 Montcouqruiol M,Valat T,Travo C, et al A role for BDNF in early post- natal rat vestibular epithelia maturation: implication of supporting cells[J]. Euro J Neurosci, 1998,10:598.

10 Emfors P,Lee KF,Jaenish R, et al Mice lacking brain-derived neu- rotrophic factor develop with sensory deficits[J]. Nature, 1994,368: 147.

11 Farinas I, Jones KR,Backus C, et al. Severe sensory and sympathetic deficits in mice lackin neurotrophin-3[J]. Nature, 1995,369:658.

12 Ylikoski J, Pirvola U, Moslnyakov M, et al. Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear[J]. Hear Res, 1993, 65:69.

13 Lefebvre PP, Malgrange B, Staecker H, et al. Neurotrophins affect sur- vival and neuritogenesis by adult injured auditory neurons in vitro[J]. Neuro-Report, 1994,5:865.

14 Zheng JL, Stewart RE, Gao WQ. Neurotrophin-4/5 enhances sur- vival of cultured spiral ganglion neurons and protects them from cis- platin neurotoxicity[J]. J Neurosci, 1995a,15:5079.

15 Zheng .JL,Stewart RR,Cao SQ. Neurotrophin-4/5,BDNF,and NT- 3 promote survival of cultured vestibular ganglion neurons and protect them againist neurotoxicity of ototoxins[J]. J Neurobiol, l995b,28: 330.

16 Fritzsch B, Silos-Santiago I, Bianchi LM, et a1. The role of neu- rotrophic factors in regulating the development of inner ear inervation[J]. Trends Neurosci, 1997,20:159.

17 Rybui F,Kokaia Z, Arco A, et al. BDNF gene transfer to the roam- malian brain using CNS-derived neural precursors[J]. Gene Ther, 1999,6:1851.

18 Klein RL, Muir D, King MA, et al. Long-term action of vector- derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferese and Trk receptor levels in the adult rat basal forebrain[J]. Neurosci,1999,90: 815.

19 Bemelmans AP, Horellou F, Pradier L, et al. Brain-derived neurotrophic factor-mediated protection of striated neurons in an ex- citotoxic rat model of Huntington' s disease, as demonstrated by mien- oviral gene transfer[J]. Hum Gene Ther,1999,10:2987.

20 Ruan RS, Leong SK, Mark J, et a1. Effects of BDNF and NT-3 on hair cells survival in guinea pig cochlea damaged by kanamycin treat- ment[J] Neuroreport, 1999,10:2067.

21 Agerman K,Canlon B,Duan M, et al. Nurotrophins,NMDA receptors, and nitric oxide in development and protection of the auditory system[J]. Ann NY Acad Sci, 1999,884:131.

22 Gao WQ. Role of neurotrophins and lectins in prevention of ototoxicity[J]. Ann NYAC&ISCI, 1999, 884:312.

23 Garrido JJ, Alonso MT. Lim F, et a1. Defining responsiveness of avian cochlear neurons to brain-derived neurotrophic factor and nerve growth factor by HSV-1-mediated gene transfer[J]. J Neurochem, 1998, 70:2336.

24 Kuang R, Hever C, Zeejic C, et al. Glial cell line-derived nets- rotrophic factor potential for otoprotection[J]. Ann NY Acad Sci, 1999,884:270.

25 Yagi M,Magal E,Sheng Z, et a1. Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cellline-derived neurotrophic factor[J]. Hum Gene Ther, 1999, 10:813.

26 Staceker H, Gabaizadeh R, Federoff H, et al. Brain-derived nurotrophic factor gene therapy prevents spiral ganglion degeneraton after hair cells[J]. Otolaryngol Head Neck Surg, 1998,119:7.

27 Weiss MA, Frisancho JC, Roessler BJ, et al. Viral-mediated gene transfer in the cochlea[J]. Int J Dev Neurosci, 1997,15:577.

28 Kahn A, Hasse C, Akli S. et al. Gene therapy of neurological disease[J]. C R Seances Soc Biol Fil, 1996,190:9.

29 Geschwind MD, Hartnick CJ, Liu W, et al.Defective HSV-1 vector expriessing BDNF in auditory ganglia elicit neurite outgrowth: model for treatment of neuron loss following cochlear degeneration[J]. Hum Gene Ther, 1996,7:173.

30 Derby ML,Sena-Esteves M, Breakefield XO, et al. Gene transfer in-to the mammalian inner ear using HSV-1 and vaccinia virus vectors[J. Hear Res, 1999,134:1

31 Wareing M, Mhatre An, Pettis R, et al. Gationic liposome mediated transgene expression in the guinea pig cochlea[J]. Hear Res, 1999, 128:61.

32 Stover T,Yagi M, Raphael Y, et al. Cochlear gene transfer: round win- dow versus cochleostomy inoculation[J]. Hear Res, 1999,136:124.

33 Stover T, Yagi M, Raphael Y, et al. Transduction of the contralateral ear after adenovirus-mediated cochlear gene transfer[J]. Gene Ther, 2000,7:377.

34 Yamasoba T,Yagi M, Roessler BJ, et al .Inner ear transgene expres- sion after adenoviral vector in oculation in the endolymphatic sac[J]. Hum Gene Ther, 1999,10:769.