金纳多对一侧迷路切除豚鼠旋转后眼震的代偿

Compensative Effect of Ginaton Following Unilateral Labyrinthectomy in Guinea Pigs

吴子明;王锦玲;王尔贵;姜鸿彦;邓瑶珠;刘顺利

1:第四军医大学西京医院耳鼻咽喉科

2:第四军医大学西京医院耳鼻咽喉科

3:解放军第414医院耳鼻咽喉科

4:第四军医大学西京医院耳鼻咽喉科

摘要
目的 观察豚鼠一侧迷路切除(unilateral labyrinthectomy,UL)后旋转后眼震的自然恢复及金纳多对(ginaton)其恢复的影响。方法 切除豚鼠左侧迷路,以其自然恢复和金纳多给药两种结果,观察旋转后眼震在不同时间恢复的差别。结果 金纳多能明显促进一侧迷路切除后旋转后眼震恢复正常并能改善两侧前庭的均衡性。一侧迷路切除后旋转后眼震频率明显下降,单纯手术组(UL组)术后眼震频率90天才恢复正常;手术+金纳多组(UL+G组)21天眼震频率与正常已无显著差别。两侧优势偏向(directional preponderance,DP)比较显示,UL组7~50天结果异常;而UL+G组自第7天起DP都在正常范围。参照旋转后眼震频率恢复情况,两侧均衡性的恢复比眼震频率恢复快。结论 金纳多能够促进动态症状的代偿,且两侧均衡性的恢复比眼震频率恢复快。
关键词
迷路切除;金纳多;前庭代偿;动态症状;豚鼠
基金项目(Foundation):
全军“九五”医学科研规划第二批科研基金课题(98M051)
作者
吴子明;王锦玲;王尔贵;姜鸿彦;邓瑶珠;刘顺利
参考文献

1 钟乃川. 耳的检查法──前庭功能检查法.见:黄选兆,汪吉宝,主 编.实用耳鼻咽喉科学[M]北京:人民卫生出版社,l998.808~827.

2 Escudero M, do Waele C, Vibert N, et al. Saccadic eye movement and the horizonal vestibulo - ocular and vestibulocollic reflexes in theintact guinea pig[J]. Exp Brain Res, 1993,97:254.

3 Cremer PD, Henderson Cj, Curthoys IS, et al. Horizonal vestibularocular reflex changes following unilateral vestibular neurectomy [J]. Neurosci Lett Suppl,1987,27:64.

4 Fetter M, Zee DS. Recovery from unilateral labyrinthectomy in rhesus monkey[J]. J Neurophysiol, 1988,59:370.

5 Lacour M, Xerri C, Hugon M. Compensation of postural reactions to fall in the vestibular neurectomized monkey: Role of the remaining labyrinthe afferents[J]. Exp Brain Res, 1979,37:563.

6 Smith PF, Curthoys IS. Mechanisms of recovery following unilateral labyrinthectomy: a review[J]. Brain Res Rev, 1989,14:155.

7 Ris L, de Waele C, Vibert N, et al. Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrithectomy in the alert guinea- pig[[J]. J Neurophysiol,1995,75:2087.

8 Yabe T, Chat M, Malherbe E, et al. Effects of ginkgo biloba extract on the guinea-pig vestibular system[J]. Pharmocol Biochem and Behay, 1992,42:595.