庆大霉素及其代谢产物对外毛细胞内游离钙浓度的影响
Gentamicin and Its Metabolite Effect [Ca~(2+)]i in Isolated Outer Hair Cells
陈贤明;王锦玲;屈玲
1:第四军医大学西京医院耳鼻咽喉科
2:第四军医大学西京医院耳鼻咽喉科
3:第四军医大学西京医院耳鼻咽喉科 西安 710033现在南京军区福州总医院耳鼻咽喉科
4:福州 350025
摘要关键词基金项目(Foundation):作者参考文献1 Nakagawa T, Kakehata S, Akaike N, et al. Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea [J]. Brain Rea, 1992,580:345.
2 Dulon D, Zajic G, Aran JM, et al. Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells[J].J Neurosci Res ,1989,24:338.
3 Huang MY, Schacht J. Formation of a cytotoxic metabolite from gentamicin by liver [J] Biochem Pliaxniacol,1990,40:R11.
4 Hudspeth AJ. The cellular basis of hearing: The biophysics of hair cells [J].Science, 1985,230:745
5 Corrado AP, Demorais IP, Prado WA Aminoglycoside antibiotics as a tool for the study of the biological role of calcium ions: Historical overview [J].Acta Physiol Pharmacol Lat Am, 1989,39:419.
6 Crann SA, Huang MY, Mclaren JD, et al. Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction [J] .Biochem Pharmacol, 1992,43:1835
7 Takada A, Schacht J. Calcium antagonism and reversibility of gentamicin- induced loss of cochlear microphonics in the guinea pig[J]. Hear Res, 1982,8:179
8 Ikeda K, Sunose H, Takasaka T. Effects of free radicals on the intracellullar calcium concentration in the isolated outer hair cell of the guineapig cochlea [J]. Acts Otolaryngol(stochh),1993,113:137
9 Song BB, Anderson DJ, Schacht J Protection from gentamicin ototoxicity by iron chelators in guinea pigs in vitro [J]. Phamacol Exp Ther,1987, 292:369.
10 陈贤明,王锦玲,姜鸿彦,等.庆大霉素引起内耳组织自由基 增加的直接证据[J].第四军医大学学报,2000,21:748.