豚鼠发育过程中前庭上皮IGF-1及IGF-1R的表达变化
Expression and Function of IGF-1 and IGF-1R in Vestibular Epithelium During the Development of Guinea Pig
胡金玮;王锦玲;黄维国;姜鸿彦;邱建华;乔莉
1:第四军医大学西京医院耳鼻咽喉科
2:第四军医大学西京医院耳鼻咽喉科
3:第四军医大学西京医院耳鼻咽喉科
4:第四军医大学西京医院耳鼻咽喉科





1 Rotwein P. Structure, evolution, expression and regulation of insulin-like growth factors 1 and 2[J]. Growth Factors, 1991,5:3.
2 Czech MP. Signal transduction by the insulin - like growth factors[J]. Cell, 1989,59:235.
3 Leon Y, Sanz JA, Vega J, et al. Insulin-like growth factor-1 regulatescell proliferation in the developing inner ear, activating glyco-sylphosphatidylinositol hydrolysis and Fos expression [J]. Endocrinol,1995,436:3494.
4 KajimotoW, Rotwein P. Structure and expression of a chicken insulin-like growth factor precursor[J]. Mol Endocrinol, 1989,3:1907.
5 Oesterle EC, Tsue TT, Rubel EW, et al. Induction of cell prolifera-tion in avian inner ear sensory epithelia by insulin - like growth factor-1 and insulin[J]. J Comp Neurol, 1997,380:262.
6 Zheng JL,Helbig C, Gao WQ, et al. Induction of cell proliferation byfibroblast and insulin - like growth factors in pure rat inner ear epithe-lial cell cultures[J]. J Neurosci, 1997, 17:216.
7 Bravo R, Frank R, Blundell PA, et al. Cyclin/PCNA is the auxiliaryprotein of DNA polymerase- delta[J]. Nature, 1987,326:515.
8 Hermond SC, Morest DK. VGanglion formation from the otic placodeand the otic crest in the chick embryo: mitosis, migration, and the basallamina[J]. Anat Embryol,1997,184:1.
9 Wouter JF, Rarey KE. Planum semilunatum of the rat: new light andelectron microscopy observations[J]. Ann Otol Rhinol Laryngol, 1992,101:601.
10 Gray EMG, Warchol ME, Corwin IT. Insulin - like growth factor -1protects hair cell from aminoglycoside induce apoptotic cell death[J].Assoc Res Otolaryngol Abstr, 1996,19:198.