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上橄榄复合体向下丘γ-氨基丁酸能投射

GABAergic Neurons of Superior Olivary Complex Projection to Inferior Colliculus

邱建华;黄维国;乔莉;刘顺利;王锦玲

1:第四军医大学西京医院耳鼻咽喉科

2:第四军医大学西京医院耳鼻咽喉科

3:第四军医大学西京医院耳鼻咽喉科

4:第四军医大学西京医院耳鼻咽喉科

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摘要

目的　研究γ－氨基丁酸（ＧＡＢＡ）阳性神经元在豚鼠上橄榄复合体的分布及向下丘的投射。方法采用辣根过氧化物酶（ＨＲＰ）逆行追踪和免疫组化ＡＢＣ技术。结果　上橄榄复合体ＨＲＰ标记神经元主要分布在双侧的上橄榄外侧核（ＬＳＯ）、同侧的上橄榄内侧核（ＭＳＯ）、上橄榄周围核（ＰＮ）及斜方体腹侧核（ＶＮＴＢ）。双侧的斜方体外侧核（ＬＮＴＢ）及背侧核（ＤＮＴＢ）未见ＨＲＰ阳性标记神经元。ＧＡＢＡ阳性反应结构在上橄榄复合体的分布具有较明显的特征性。阳性神经元主要分布在ＬＳＯ、ＤＮＴＢ及ＰＮ内，多呈圆形、卵圆形，直径约１６～４０μｍ，突起较短。阳性点状终末主要分布在ＶＮＴＢ及ＬＮＴＢ，以ＶＮＴＢ数量较多。ＬＳＯ和ＰＮ内均发现ＨＲＰ－ＧＡＢＡ双标细胞，约占标记细胞的三分之一。结论　豚鼠上橄榄复合体有ＧＡＢＡ阳性神经元和终末分布；橄榄内侧和外侧系统均有向下丘投射的神经元；在ＬＳＯ、ＤＮＴＢ和ＰＳＯ内，有ＧＡＢＡ能神经元向下丘的上行投射。

关键词

γ-氨基丁酸;辣根过氧化物酶;上橄榄复合体;下丘;豚鼠

基金项目(Foundation):

作者

邱建华;黄维国;乔莉;刘顺利;王锦玲

参考文献

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