梅尼埃病血清抗Ⅱ型胶原抗体的研究

Anti-Type Ⅱ Collagen Antibody in Theserum of Patients With Meniere's Disease

黄魏宁;宋海涛;胡刚;廉能静;孟曦曦;王秀梅;王冲;刘桂芳

1:卫生部北京医院耳鼻咽喉科!北京

2:100730

3:卫生部北京医院耳鼻咽喉科!北京

4:100730

摘要
目的了解梅尼埃病与自身免疫之间的关系。方法测试了30例正常人和30例梅尼埃病患者血清中的非特异性免疫球蛋白(IgG、IgM和IgA),补体(C3和C4),以及抗Ⅱ型胶原抗体。结果梅尼埃病患者血清中非特异性IgG、IgM和IgA以及C3和C4均在正常范围;而患者中53.3%的抗Ⅱ型胶原抗体IgG明显增高,在正常对照组的血清中抗Ⅱ型胶原抗体均不增高。结论自身免疫反应可能是该病的原因之一。
关键词
梅尼埃病;抗Ⅱ型胶原抗体;自身免疫
基金项目(Foundation):
作者
黄魏宁;宋海涛;胡刚;廉能静;孟曦曦;王秀梅;王冲;刘桂芳
参考文献

1Tomoda K,Suzuka Y,Iwai H,et al.Meniere's disease and autoimmunity:clinical study and survey.ActaOtolaryngol(Suppl),1993,500:31.

2Dornhoffer JL, Waner M,Arenberg IK.et al.Immunoperoxidase study of the endolymphatic sac in Meniere's disease.Laryngoscope, 1993.103:1027.

3Tomiyama S.Development of endolymphatic hydrops following immune response in the endolymphatic sac of the guineapig.Acta Otolaryngol,1992,112:470.

4Soloman AM.Experimental autoimmune inner ear disease.Laryngoscope,1989,99:188.

5Unk K.Miyamura K,Kanzaki Y,et al.Type I allergy in theinner ear of the guinea pig.Ann Otol Rhinol Larynglo(Suppl),1992.157:78.

6Lee FP,Ho TL,Huang Ts.Endolymphatic hydrops in animalexperiments,A confirmation of mechanical andimmunological methods of inducement.Acta Otolaryngol(Suppl),1991,485:18.

7张学渊,袁伯庆.人Ⅱ型胶原免疫豚鼠至内耳损坏的研究.中华耳鼻咽喉科杂志, 1992,27: 11.