乙酰胆碱对游离外毛细胞的影响

Effect of Acetylcholine on Outer Hair Cells

邓毅;陈兆和;王健;王宇澄

1:南京大学医学院鼓楼医院耳鼻咽喉科

2:南京大学医学院鼓楼医院耳鼻咽喉科

3:南京大学医学院鼓楼医院耳鼻咽喉科

4:南京大学医学院鼓楼医院耳鼻咽喉科 210008

摘要
文中将分离的外毛细胞分别置于含5mM乙酰胆碱(Ach)的Hank平衡液(Hank’s bal- ance solution,HBS)以及含钙拮抗剂0.5mM Verapamil+5mM Ach的HBS中.发现外毛细胞处于含有5mM Ach的HBS中2分钟内短缩,之后,细胞长度不再继续改变;在含有钙拮抗剂的HBS中,游离的外毛细胞不发生短缩现象.表明Ach使外毛细胞短缩,而且Ach使外毛细胞的收缩可被钙拮抗剂所抑制.实验提示Ach-Ach受体系统为外毛细胞主动活动的主要调控系统.
关键词
外毛细胞;神经递质;乙酰胆碱;异搏停
基金项目(Foundation):
作者
邓毅;陈兆和;王健;王宇澄
参考文献

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邓毅陈兆和王健王宇澄