现代分子生物学技术在耳科研究领域中的应用──内耳发育中的转录因子实验研究(上)
陈晓巍;曹克利
1:北京协和医院耳鼻咽喉科
lHoganB.Themakingoftheear.Nature,1992,355:494~495.2DavidPC.Transcriptionfactorsininnereardevelopment.Ptoc.Nat1.Ac3dSci,1994,91:433~436.3敖世洲,主编.基因分子生物学研究进展.上海:上海科学技术出版社,1992,80~88.4LufkinT.DisruptionoftheHox-1.6homeoboxgeneresultsindefectsinaregioncorrespondingtoitsrostraldomainofexpression.Cell,1991,66:ll05~1119.5ChisakaO.Developmentaldefectaloftheear,cranicalnervesandhindbbainresultingfromtargeteddisruptionofthemousehomeoboxgeneHox-l.6.Nature,1992,355:516~520.6TassabehjiM.Waardenburg'ssyndromepatientshavemutationsinthehumanbomologueofthePax-3pairedboxgene.Nature,l992,355~636.7KelleyMW,Thedevelopingorganofcorticontainsretinoicacidandformssupernumeraryhaircellinresponsetoexogenousretinoicacidinculture.Dvvelopment,1993,119:1041~1055.8BradleyDJ.αandβ-thyroidhormonereceptor(TR)geneexpressionduringauditorynerogenesis,Evidenceforisoform-specifictranscriptionalregulationinvivo.Proc.Natl.AcadSci,1994,9l:439~443。9KesselM.Murinedevelopmentalcontrolgenes.Science,199O.249:374.