甲状腺功能低下对ABR和DPOAE的影响

The Effect of Experimental Hypothyroidism on ABR and DPOAE

王德辉;张玉海;王正敏;步星耀

1:上海医科大学附属眼耳鼻喉医院耳研中心

2:上海医科大学

摘要
为了探讨甲状腺功能低下(甲低)时听觉功能损害的部位及可能的致病机理,用含甲硫咪唑(0.15g/L)的饮用水喂养大鼠制造甲低模型,对甲低前后的大鼠进行听性脑干反应(ABR)和畸变产物耳声发射(DPOAE)的检测。结果发现:甲低后ABR阈值明显升高;而ABR各波潜伏期及波间期无明显变化。DPOAE“听力图”显示甲低后DPOAE振幅明显下降;DPOAE阈值明显上升。提示耳蜗是甲低时听觉功能损害的主要部位,文中对可能的发病机理进行了讨论。
关键词
听性脑干反应;畸变产物;耳声发射;甲状腺功能低下;耳蜗
基金项目(Foundation):
作者
王德辉;张玉海;王正敏;步星耀
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