【Abstract】 Objective To study the cinical effect of oral localization therapy combined with conductive education on children with speech-language disorders. Methods Using random number table method，84 children with speech-language disorder from July 2018~ December 2019 were divided into control group and observation group, with 42 cases in each group. The control group was given routine speech training, while the observation group was given oral localization therapy combined with conductive education on the basis of the control group, once daily for 40 minutes, 5 times a week, 4 weeks as 1 course of treatment, and 3 consecutive courses of treatment. Before and after treatment, respectively using simple oral movement function scale, Frenchay Chinese version of dysarthria detection table, voice clarity detection table, and Gesell growth detection table to evaluate the oral movement function, conformational situation,speech clarity, and language behavior ability of two groups. The language development assessment method of Chinese children(S-S) was used to evaluate the clinical efficacy of two groups of children.Results Before treatment, there was no significant difference between the two groups in oral motor function score, construction sound, speech clarity and language behavior score (P>0.05).After 3 courses of treatment, the scores of motor function, construction sound, speech clarity and language behavior of the two groups were significantly improved. The scores of the observation group were significantly higher than the control group,the difference was statistically significant (P<0.05).The total effective rate was 73. 81% in the control group and 95. 24% in the observation group. There was significant difference between the two groups (P<0.05).Conclusion Oral localization therapy combined with conductive education can significantly promote the rehabilitation of children with speech-language disorders, and the effect is significant.