SISI联合TEOAE在噪声性听力损失筛查中的应用

Application of SISI Combined with TEOAE in the Hearing Screening of Noise Included Hearing Loss

池君;宋武战;刘丹;游建军;

1:解放军联勤保障部队第九二〇医院耳鼻咽喉头颈外科

2:解放军联勤保障部队第九二〇医院急诊医学科

3:武汉大学附属口腔医学院牙体牙髓科

4:湖北省计量科学院计量所

摘要
目的 探讨短增量敏感指数(SISI)测试及瞬态诱发耳声发射(TEOAE)在噪声性听力损失筛查中的意义。方法 50例纯音听阈正常并有噪声暴露史的受试者作为噪声组,另外50例未接受噪声暴露的纯音听阈正常者作为对照组,两组平均年龄分别为19.58±1.03、19.90±1.20岁。两组分别行气导纯音听阈、SISI、TEOAE检测,分析两组间的结果差异。结果 噪声组和对照组0.25~8 kHz气导纯音听阈均小于20 dB HL,差异无统计学意义(P>0.05)。噪声组各频率SISI均高于对照组,差异有显著统计学意义(P<0.01)。噪声组TEOAE波形总体相关率为92.32%±1.99%,对照组为97.92%±0.49%(P<0.05);噪声组反应幅值为16.00±1.04 dB SPL,对照组为20.27±0.70 dB SPL(P<0.05);噪声组信噪比为12.66±1.55 dB,对照组为20.95±0.89 dB(P<0.01)。SISI 6 kHz与TEOAE 3.5~4.5 kHz频段信噪比负相关(P<0.05)。结论 高频率SISI联合提高筛查标准的TEOAE指标可为噪声性听力损失提供早期的诊断途径。

【Abstract】 Objective To study the value and significance of short increment sensitivity index (SISI) and transient evoked otoacoustic emissions (TEOAE) in the hearing screening of noise induced deafness with normal pure tone hearing threshold. Methods Fifty young adults with normal pure tone bearing threshold and a history of noise exposure participated in the study, in addition fifty subjects without noise exposure were included as the control group. The average age of the experimental group and the control group were 19.58±1.03 and 19.90±1.20 years old, respectively. Pure tone audiometry, SISI and TEOAE were performed. Statistical analysis was performed to analyze differences between two groups. Results The pure tone hearing thresholds from 0.25 kHz to 8 kHz in control group and noise group were less than 20 dB HL. No significant differences were found (P>0.05). The SISI of noise group were higher than that of normal group, and significant differences were found (P<0.01).The total correlation rate of TEOAE waveform in noise group and control group was 92.32%±1.99% and 97.92%士0.49%,respectively (P<0.05).The response intensity in noise group and control group was 16. 00±1.04 dB SPL and 20. 27±0. 70 dB SPL (P<0.05).The overall SNR in the noise group and control group was 12.66±1.55 dB and 20.95±0.89 dB, respectively (P<0.01). SISI of 6 kHz was negative correlated with TEOAE 3.5~4.5 kHz SNR(P<0.05).Conclusion High frequency SISI combined with TEOAE of higher screening standards can provide an early diagnosis strategy for noise-induced deafness.


关键词
噪声性听力损失;短增量敏感指数;瞬态诱发耳声发射
基金项目(Foundation):
作者
池君;宋武战;刘丹;游建军;
参考文献

1 Carney LH.Supra-threshold hearing and fluctuation profiles:implications for sensorineural and hidden hearing loss[J].J Assoc Res Otolaryngol,2018,19(4):331-352.

2 Vaden KI Jr,Matthews LJ,Dubno JR.Transient-evoked otoacoustic emissions reflect audiometric patterns of age-related hearing loss[J].Trends Hear,2018,22:1-13.

3 Putterman DB,Keefe DH,Hunter LL,et al.Assessing sensorineural hearing loss using various transient-evoked otoacoustic emission stimulus conditions[J].Ear Hear,2017,38(4):507-520.

4 Kurabi A,Keithley EM,Housley GD,et al.Cellular mechanisms of noise-induced hearing loss[J].Hear Res,2017,349(2):129-137.

5 Moshammer H,Kundi M,Wallner P,et al.Early prognosis of noise-induced hearing loss[J].Occup Environ Med,2015,72(2):85-89.

6 Liberman MC.Noise-induced and age-related hearing loss:new perspectives and potential therapies[J].F1000Res,2017,16(6):1-11.

7 Chang MY,Han SY,Shin HC,et al.Protective effect of a purified polyphenolic extract from Ecklonia cava against noise-induced hearing loss:prevention of temporary threshold shift[J].Int J Pediatr Otorhinolaryngol,2016,87(8):178-184.

8 Xie R,Manis PB.Synaptic transmission at the endbulb of held deteriorates during age-related hearing loss[J].J Physiol,2017,595(3):919-934.

9 Liberman MC,Kujawa SG.Cochlear synaptopathy in acquired sensorineural hearing loss:manifestations and mechanisms[J].Hear Res,2017,349(3):138-147.

10 Graham CE,Basappa J,Turcan S,Vetter DE.The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma[J].Mol Neurobiol,2011,44(3):383-406.

11 Putterman DB,Keefe DH,Hunter LL,et al.Assessing sensorineural hearing loss using various transient-evoked otoacoustic emission stimulus conditions[J].Ear Hear,2017,38(4):507-520.