中等强度噪声暴露对幼年豚鼠听觉中枢的影响
Effects of Moderate Noise Exposure on Auditory Center of Juvenile Guinea Pigs
林莹;戴晨逸;苏婷卉;应航;徐飞;
1:浙江中医药大学医学技术与信息工程学院
摘要【Abstract] Objective To investigate the effect of 85 dB SPL white noise exposure on the central auditory pathway and auditory behavior of juvenile guinea pigs, so as to provide reference for the study of the latent harm of noise. Methods Ten 3-week-old guinea pigs were randomly divided into the experimental group and the control group, with 5 guinea pigs in each group. The experimental group was exposed to 12 hours daily white noise (85 dB SPL) for 4 weeks. The auditory electrophysiological test (DPOAE,ABR,GIN-ABR)and acoustic startle reflex(ASR) test were performed at the end of exposure and two weeks after exposure. The control group was fed to 7 weeks old in a quiet environment for the above tests, and the results of the two groups were compared. Results At the end of exposure, the DPOAE amplitude of 16 kHz in the experimental group decreased significantly (P<0.01), and it recovered two weeks after exposure. At the end of exposure day, the ABR threshold of 12 kHz (P<0.05) and 16 kHz (P<0.01) in the experimental group increased significantly, and recovered two weeks after exposure. The wave IV amplitude of 6 kHz (P<0.05) and 8 kHz (P<0.01) without threshold shift decreased significantly, and did not recover two weeks after exposure (P<0.05). Two weeks after exposure, the amplitude of GIN-ABR wave IV in the 4 ms gap of the experimental group was still significantly lower than that of the control group (P<0.05), and the ASR amplitude of the 100 dB SPL stimulus had a tendency to decrease in the experimental group. Conclusion Eighty five dB SPL white noise exposure did not cause permanent threshold shift in young guinea pigs, but weakened the brainstem auditory response activity of guinea pigs in adulthood, and led to changes in their suprathreshold auditory function (temporal processing).
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