基于fMRI的内源性注意下视听整合的脑网络研究
Study on Brain Network of Audiovisual Integration under Endogenous Attention Revealed by fMRI
管中天;燕明丽;林萌;王松建;张娟;王宁宇;张旭;李春林
1:首都医科大学生物医学工程学院
2:首都医科大学大数据精准医疗高精尖创新中心
3:首都医科大学临床生物力学应用基础研究北京市重点实验室
4:北京大学第一医院
【Abstract] Objective To study the effective connection of audiovisual integrated brain network under the regulation of endogenous attention. Methods Twenty five young adults (average age 24±2 years old, all right-handed) with normal audiovisual and cognitive ability were selected as subjects. Audiovisual attention task, visual attention task and auditory attention task based on Posner paradigm were used and fMRI technology was applied to collect brain imaging data. Significant differences in activation of brain regions between three tasks were analyzed. Granger causality analysis was applied to identify effective connections between differentially activated brain regions. Results Basic sensory cortex such as inferior occipital gyrus (IOG) , middle occipital gyrus (MOG), superior temporal gyrus (STG), lingual gyrus (LING) and dorsal frontoparietal network such as precentral gyrus (PreCG),precuneus(PCUN), supplementary motor area(SMA),inferior parietal lobule (IPL) were all extensively activated in three tasks. The results of Granger causality analysis showed that there were six significant differential connections between audiovisual attention task and visual attention task(SMA. L→IOG.L, PCUN.R→IPL. L,STG.L→PreCG. R,MOG.L→MOG.R,IOG. L→PreCG.L, IOG. R→IPL. L) and three significant differential connections between audiovisual attention task and auditory attention task (IPL.L→MOG. L, STG.L→PreCG. R, STG. L→LING. R). Conclusion Two-way significant differential connections between the frontoparietal network and the basal sensory cortex were found under the regulation of endogenous attention, revealing the brain network mechanism that the process of audiovisual integration depends on the feedforward and feedback information flows between the frontoparietal network and the basal sensory cortex.
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