GSTP1及SOD2基因多态性与噪声性听力损失易感性的关系
Relationship between GSTP1 and SOD2 Gene Polymorphisms and Noise-induced Hearing Loss Susceptibility
郑雪丽;朱宏;王成进;徐学海;陈文渊;李萍;何晓菲
1:河西学院附属张掖人民医院耳鼻咽喉头颈外科
2:河西学院临床医学院
3:甘肃省妇幼保健院耳鼻咽喉头颈外科
摘要【Abstract】 Objective To explore the relationship between glutathione Stransferase (GST) P1 gene (GSTP1) and superoxide dismutase 2 (SOD2) gene polymorphisms and susceptibility to noise-induced hearing loss (NIHL).Methods Using the 1 : 1 nested case-control study method， 262 NIHL patients were selected from the research cohort of noise workers in a steel as the hearing loss group. A total of 262 subjects with normal hearing whose age difference was ≤5 years and noise working age difference was ≤2 years were recruited as the control group and were matched according to the gender and type of work of the patients. High-throughput single nucleotide polymorphism (SNP) typing detection technology was used to detect the polymorphisms at rs1695， rs6591256 of GSTP1 gene and rs2758343，rs2758346，rs4880，rs5746105 of SOD2 gene. Logistic regression typing was used to analyze the relationship between single-site polymorphism and NIHL susceptibility，and COX regression was used to analyze the risk of NIHL in individuals with different genotypes. Results Logistic regression analysis showed that the risk of NIHL susceptibility for individuals carrying the G allele gene at the rs1695 locus of the GSTP1 gene was1.446 times (95%CI:1.110~1.882，P<0.05). For individuals carrying the G allele gene at the rs6591256 locus, the risk of NIHL susceptibility of individuals was 1.570 times that of A allele (95%CI: 1.205~2.046，P<0.05). Individuals who carry AA allele at rs5746105 of SOD2 gene were susceptible to NIHL risk of GG+GA,etc. 1.689 times of the locus gene (95%CI: 1.117~2.556,P<0.05).COX regression analysis showed that with the extension of working years, the risk of NIHL carrying the G allele gene at the rs1695 locus of the GSTP1 gene was 1. 202 times that of the A allele gene (95%CI:1.039~1.391, P<0.05). For NIHL individuals with rs6591256 locus carrying the G allele gene, the risk of allele gene NIHL was 1. 159 times that of A allele gene (95%CI: 1.002~1.342， P<0.05).Conclusion The G allele gene at rs1695 and rs6591256 of GSTP1 gene, and gene A at rs5746105 of SOD2 gene may be risk factors for NIHL.
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