难治性突发性聋研究进展

谭鑫源;张宏征

1:南方医科大学珠江医院耳鼻咽喉头颈外科中心

摘要
<正>突发性聋(sudden hearing loss,SHL)的治疗主要以全身糖皮质激素(glucocorticoid,GC)治疗为主,但是部分患者经过综合治疗后听力未见明显改善。经过10~14天全身糖皮质激素为主综合治疗后听力改善不佳者为难治性突发性聋(refractory sudden hearing loss,RSHL)([1,2])。然而对RSHL的判定标准尚未统一,有学者建议以初始GC治疗后气导平均纯音听阈(PTA)改善小于15dB([1,2])。然而对RSHL的判定标准尚未统一,有学者建议以初始GC治疗后气导平均纯音听阈(PTA)改善小于15dB([1])~30dB([1])~30dB([2,3])为标准,而IFOS国际共识认为任何>10dB的PTA变化都不容忽视([2,3])为标准,而IFOS国际共识认为任何>10dB的PTA变化都不容忽视([4])。本文对RSHL的发病机制、治疗进展进行综述,旨在为该病的临床和基础研究提供新的思路。
关键词
基金项目(Foundation):
广东省科技计划项目(2019A141401003)
作者
谭鑫源;张宏征
参考文献

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谭鑫源张宏征